The role of vasopressin V1A and oxytocin OTR receptors in protective effects of arginine vasopressin against H₂O₂-induced oxidative stress in H9C2 cells

Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure

“…Cells in other groups were not transfected. After transfection, the cells in the model group were exposed to 100 μM H 2 O 2 solution (6 h) or 200 μM ISO solution (24 h) in DMEM without FBS to simulate oxidative damage model in vitro [ 9 , 10 ], and the cells in the Tiron group were administrated 100 μmmol/L Tiron for 2 h [ 11 ]. Cells in the other groups were treated with the same amount of DMEM without FBS.…”

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

“…Interestingly, all these pathways are inter-related with redox processes, e.g. melatonin has antioxidant properties [ 176 ], the glutamate-NOS pathway stimulates oxidative stress [ 173 ], while vasopressin and oxytocin have protective effects under conditions of oxidative stress in vitro [ 177 ]. Chronic stress alters the structural integrity of GABAergic neurons [ 178 ] that disinhibits the amygdala [ 179 ], most likely accounting for increased worry symptoms ( Fig.…”

“…When considered with its earlier mentioned ( see Agomelatine ) role as anti-COVID-19 adjunctive therapy [ 271 ], melatonin is a strong candidate that requires further investigation. Similarly, oxytocin-vasopressin exert actions on redox systems [ 177 ] while their delicate balance is implicated in anxiety disorders [ 175 ]. In this regard, oxytocin has been noted to have potential as an adjuvant treatment in COVID-19 infection [ 296 ].…”

Oxytocin Receptor Signaling in Vascular Function and Stroke

“…Critically, in a parallel but inverse set of discoveries, the use of OXTR antagonists lead to an increase in markers of oxidative stress in cardiac tissue (Simsek et al, 2012). In cardiac cells and in vivo rat hearts a protective effect for vasopressin, and specifically vasopressin acting at V1aR and OXTRs has been reported to reduce oxidative stress (Nazari et al, 2015;Ghorbanzadeh et al, 2020). So in regard to OXT and OXTR roles in oxidative stress, complete independence from the arginine-vasopressin system cannot be assumed.…”

“…Lastly, OXT administration enhances the uptake of glucose both peripherally in skeletal and cardiac cells ( Lee et al, 2008 ; Florian et al, 2010 ), and centrally in non-human primates after intranasal administration ( Arias del Razo et al, 2020 ). Another option is, again, the observed pro-survival and glucose metabolism supporting effects as evidenced by vasopressin administration and V1aR knockout animals ( Aoyagi et al, 2007 ; Ghorbanzadeh et al, 2020 ). While the existing evidence is minimal, and little has been tested centrally, there are reports of some enhancement of cell survival, including under ischemic conditions, for OXT and OXTR signaling.…”