Oxytocin Receptor Signaling in Vascular Function and Stroke

McKay, Erin; Counts, Scott

doi:10.3389/fnins.2020.574499

Cited by 23 publications

(18 citation statements)

References 265 publications

(395 reference statements)

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“…As OT has pleiotropic effects, the therapeutic perspectives are truly exciting. Indeed, OT has broad implications for general health: OT is a stress-coping molecule with anti-inflammatory and antioxidant properties; influences the immune system, body composition, cognitive functions and mood; and has been tested in the treatment of numerous diseases, including anxiety, pain, diabetes, cardiovascular diseases and breast cancer [1,27,[40][41][42][43][44][45].…”

Section: Oxytocin As a Therapeutic Agent: Perspectivesmentioning

confidence: 99%

“…OT is recognized to play a role in social behavior and stress coping, is involved in the regulation of hippocampal plasticity and memory formation, and increases the functional activity and connectivity in frontal regions associated with the impairment in autism [41,58]. It has been reported that the OT receptors' polymorphisms are associated with impaired memory in humans, and OT knockout in mice displays memory deficit [43]. A systematic review of the effects of OT treatment in frontotemporal dementia reports an improvement in cognition and behavioral symptoms with a good tolerance [58].…”

Section: Oxytocin As a Therapeutic Agent: Perspectivesmentioning

confidence: 99%

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Oxytocin and Bone: Review and Perspectives

Breuil

Trojani

Amri

2021

IJMS

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Recent data demonstrate the anabolic effect of oxytocin on bone. Bone cells express oxytocin receptors. Oxytocin promotes osteoblasts differentiation and function, leading to an increased bone formation with no effect on bone resorption and an improvement of bone microarchitecture. Oxytocin is synthetized by osteoblasts, and this synthesis is stimulated by estrogen. Animal studies demonstrate a direct action of oxytocin on bone, as the systemic administration of oxytocin prevents and reverses the bone loss induced by estrogen deficiency. Although oxytocin is involved in bone formation in both sexes during development, oxytocin treatment has no effect on male osteoporosis, underlining the importance of estrogen that amplifies its local autocrine and paracrine secretion. There are few human data showing a decrease in the oxytocin serum level in anorexia nervosa independently of estrogen and in amenorrheic women associated with impaired bone microarchitecture; in post-menopausal women a higher oxytocin serum level is associated with higher bone density, but not in osteoporotic men. Oxytocin displays many effects that may be beneficial in the management of osteoporosis, cardiovascular diseases, cognitive disorders, breast cancer, diabetes and body fat gain, all age-related diseases affecting elderly women, opening exciting therapeutic perspectives, although the issue is to find a single route, dosage and schedule able to reach all these targets.

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Section: Oxytocin As a Therapeutic Agent: Perspectivesmentioning

confidence: 99%

Section: Oxytocin As a Therapeutic Agent: Perspectivesmentioning

confidence: 99%

Oxytocin and Bone: Review and Perspectives

Breuil

Trojani

Amri

2021

IJMS

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“…The cardiovascular system is one of oxytocin’s important targets [ 2 , 3 ]. Oxytocin and its receptors are expressed in the heart and its vascular cells [ 4 ]. In the cultured brain microvascular endothelial cells (BMEC), oxytocin inhibits ox-LDL-induced monocyte adhesion to BMEC and the expression of adhesion molecules [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Chronic administration of oxytocin reduces atherosclerotic plaque and inflammation in the aorta of ApoE -/- mouse [ 6 ]. It has been proposed that the intrinsic oxytocin system may play a critical role in the maintenance of cardiovascular homeostasis [ 2 , 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Oxytocin-induced endothelial nitric oxide dependent vasorelaxation and ERK1/2-mediated vasoconstriction in the rat aorta

Zhuo

Zhang

et al. 2022

Korean J Physiol Pharmacol

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Oxytocin is a neuropeptide produced primarily in the hypothalamus and plays an important role in the regulation of mammalian birth and lactation. It has been shown that oxytocin has important cardiovascular protective effects. Here we investigated the effects of oxytocin on vascular reactivity and underlying the mechanisms in human umbilical vein endothelial cells (HUVECs) in vitro and in rat aorta ex vivo. Oxytocin increased phospho-eNOS (Ser 1177) and phospho-Akt (Ser 473) expression in HUVECs in vitro and the aorta of rat ex vivo. Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), inhibited oxytocin-induced Akt and eNOS phosphorylation. In the rat aortic rings, oxytocin induced a biphasic vascular reactivity: oxytocin at low dose (10 -9 -10 -8 M) initiated a vasorelaxation followed by a vasoconstriction at high dose (10 -7 M). L-NAME (a nitric oxide synthase inhibitor), endothelium removal or wortmannin abolished oxytocin-induced vasorelaxation, and slightly enhanced oxytocin-induced vasoconstriction. Atosiban, an oxytocin/ vasopressin 1a receptor inhibitor, totally blocked oxytocin-induced relaxation and vasoconstriction. PD98059 (ERK1/2 inhibitor) partially inhibited oxytocin-induced vasoconstriction. Oxytocin also increased aortic phospho-ERK1/2 expression, which was reduced by either atosiban or PD98059, suggesting that oxytocin-induced vasoconstriction was partially mediated by oxytocin/V1aR activation of ERK1/2. The present study demonstrates that oxytocin can activate different signaling pathways to cause vasorelaxation or vasoconstriction. Oxytocin stimulation of PI3K/eNOS-derived nitric oxide may participate in maintenance of cardiovascular homeostasis, and different vascular reactivities to low or high dose of oxytocin suggest that oxytocin may have different regulatory effects on vascular tone under physiological or pathophysiological conditions.

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“…Oxytocin was first discovered in 1906 for its uterine-contracting properties [ 1 ] and shortly after, its involvement in lactation was described [ 2 , 3 ]. Since the beginning of the 20th century, numerous studies have revealed the involvement of oxytocin in a range of biological functions, including cell growth and regulation, wound healing, and anti-inflammatory actions as well as social behaviors such as mother–infant attachment and pair-bonding [ 4 , 5 , 6 , 7 , 8 ]. Along this line of research, compelling evidence has accumulated, establishing the role of oxytocin in appetite regulation, eating behavior, weight status, and metabolism in both animal models and humans [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans

Kerem

Lawson

2021

IJMS

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The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological processes, including parturition, lactation, cell growth, wound healing, and social behavior. More recently, increasing evidence has established the effects of oxytocin on food intake, energy expenditure, and peripheral metabolism. In this review, we provide a comprehensive description of the central oxytocinergic system in which oxytocin acts to shape eating behavior and metabolism. Next, we discuss the peripheral beneficial effects oxytocin exerts on key metabolic organs, including suppression of visceral adipose tissue inflammation, skeletal muscle regeneration, and bone tissue mineralization. A brief summary of oxytocin actions learned from animal models is presented, showing that weight loss induced by chronic oxytocin treatment is related not only to its anorexigenic effects, but also to the resulting increase in energy expenditure and lipolysis. Following an in-depth discussion on the technical challenges related to endogenous oxytocin measurements in humans, we synthesize data related to the association between endogenous oxytocin levels, weight status, metabolic syndrome, and bone health. We then review clinical trials showing that in humans, acute oxytocin administration reduces food intake, attenuates fMRI activation of food motivation brain areas, and increases activation of self-control brain regions. Further strengthening the role of oxytocin in appetite regulation, we review conditions of hypothalamic insult and certain genetic pathologies associated with oxytocin depletion that present with hyperphagia, extreme weight gain, and poor metabolic profile. Intranasal oxytocin is currently being evaluated in human clinical trials to learn whether oxytocin-based therapeutics can be used to treat obesity and its associated sequela. At the end of this review, we address the fundamental challenges that remain in translating this line of research to clinical care.

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Oxytocin Receptor Signaling in Vascular Function and Stroke

Cited by 23 publications

References 265 publications

Oxytocin and Bone: Review and Perspectives

Oxytocin and Bone: Review and Perspectives

Oxytocin-induced endothelial nitric oxide dependent vasorelaxation and ERK1/2-mediated vasoconstriction in the rat aorta

The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans

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