The role of urinary hepcidin in early detection of iron deficiency anemia

Mouhamed, Hala I; Sheimy, Aisha El; Omran, Azza; Mohamed, Youssof; Helmy, Fify; Ali, Sohaila

doi:10.4103/jmisr.jmisr_52_18

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Present data were in agreement with previous studies. 37,38 For urinary hepcidin, an AUC of 0.875 was obtained with the best combination of diagnostic sensitivity (82.6%) and specificity (83.1%) at a cutoff value of 199 ng/mg. About 24.5% of young females were diagnosed to be iron deficient based on urinary hepcidin cutoff value.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India

2021

View full text Add to dashboard Cite

Introduction Iron deficiency is one of the most common nutritional disorders in the world affecting young females of the reproductive age group. Indeed, an ideal screening test should be capable of identifying iron deficiency long before developing anemia. Henceforth, the present study was aimed to determine utility of hepcidin in iron deficiency and to see its correlation with different iron indices. Methods This cross-sectional study was conducted in the Department of Biochemistry, SGT Medical College Hospital and Research Institute, Budhera, Gurugram, Haryana, India. It included 200 nonpregnant female students aged between 18 and 25 years. Estimation of hepcidin was by enzyme-linked immunosorbent assay. Quantitative estimation of serum iron, total iron-binding capacity (TIBC), and transferrin saturation was done via semi-autoanalyzer. Statistical analysis was done using SPSS v22. Results The reference range of urinary hepcidin established in this study was 110 to 969 ng/mg creatinine (mean ± standard deviation 328.3 ± 195.07 ng/mg creatinine). Serum hepcidin and urinary hepcidin had a significant correlation with iron indices. Area under the curve of urinary hepcidin was obtained with best combination of diagnostic sensitivity (82.6%) and specificity (83.1%) at a cutoff value of > 15.7 ng/mL and ≤ 199 ng/mg, respectively. Conclusion Since ferritin, TIBC, transferrin saturation, and hepcidin each represent different aspects of iron metabolism, incorporating hepcidin in the present diagnostics and combined evaluation of these indices may accord enhanced clinical information. Hepcidin would help to stratify the vulnerable young healthy female population in early stages of iron deficiency and guide proper interventions to reduce morbidity.

show abstract

Section: Discussionmentioning

confidence: 99%