The role of ultrasound in controlling the liquid-liquid phase separation and nucleation of vanillin polymorphs I and II

Parimaladevi, P.; Supriya, S.; Srinivasan, K.

doi:10.1016/j.jcrysgro.2017.12.023

Cited by 26 publications

(25 citation statements)

References 19 publications

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“…Volatile aromatic components undergo mainly pyrolitic degradation, while aromatics with hydrophilic characteristics are degraded predominantly via the radical chain mechanism. The latter degrade mainly at intermediate frequencies between 165 and 850 kHz while the volatile aromatic components show higher degradation rates at low ultrasound frequencies (around 20 kHz) [137,143]. In addition, these volatile aromatic components can be removed from the solution due to evaporation in the degassing-bubbles created via sonication [144].…”

Section: Related To Size and Number Of Cavitation Bubblesmentioning

confidence: 99%

“…Second is the disruption of such dimerization due to the electric field around a cavitation bubble. However, the reason for low power ultrasound to support the metastable polymorph was not understood.In a work by Parimaladevi et al pulsed ultrasound was used to control the polymorph ofVanillin in evaporative crystallization[165]. The solution was sonicated at varying power, pulse rate and total sonication time at a constant frequency of 20 kHz.…”

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confidence: 99%

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Sonocrystallisation: Observations, theories and guidelines

Jordens

Gielen

Xiouras

et al. 2019

Chemical Engineering and Processing - Process Intensification

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Crystallization is an important and widely used separation technique in the chemical and pharmaceutical industry. Control of the final particle properties is of great importance for these industries. The application of ultrasound in these crystallization processes, also referred to as sonocrystallization, has shown to impact nucleation, crystal growth and fragmentation. As a result this technology has potential to control the final particle size, shape and polymorphic form.This review provides a comprehensive overview of the recent advances in sonocrystallization. It reviews the observed effects of ultrasound on the different stages of the crystallization process. Recent insights in the mechanism behind these effects are discussed as well. Finally, guidelines for the operating conditions, such as ultrasonic frequency, power, type of cavitation bubbles, time window and moment of application are formulated.

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Section: Related To Size and Number Of Cavitation Bubblesmentioning

confidence: 99%

mentioning

confidence: 99%

Sonocrystallisation: Observations, theories and guidelines

Jordens

Gielen

Xiouras

et al. 2019

Chemical Engineering and Processing - Process Intensification

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“…Organic molecules are inherently flexible, and it is intuitive to expect the NNTRB to increase with the molecular weight (MW). The analysis of recent literature reveals that the increase of occurrence of LLPS 12–17 seems linked to the chronological increase of MW and lipophilicity of candidate drugs 5–11.…”

Section: Introductionmentioning

confidence: 99%

“…Reports about theories of LLPS and methods to overcome it have been steadily increasing in recent years. In the absence of seeds, the use of ultrasound 13, 14, adjustment of solvent composition (polarity), and seeding 15, 16, 29 were successful in overcoming LLPS and isolating first crystals. De Albuquerque and Mazzotti 33 reported an elegant method to avoid LLPS based on thermodynamic modeling to generate the phase diagram.…”

Section: Introductionmentioning

confidence: 99%

A Pathway to First Crystals for Substances Prone to Liquid‐Liquid Phase Separation

Derdour

2021

Chem Eng & Technol

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An approach to isolate first crystals for molecules prone to liquid‐liquid phase separation (LLPS) is described. In the absence of knowledge about the solubility of a hypothetical crystal, it is proposed to determine the LLPS phase boundary, then operate at a temperature of 2 °C above the LLPS to maximize the supersaturation with respect to a hypothetical crystalline phase and to avoid LLPS. The proposed approach, combined with a careful solvent and counterion selection based on molecular size, allowed isolating a crystalline salt that was elusive using high‐throughput screening. The crystalline salt displayed higher resistance to mechanical stress than the crystalline parent, allowing the progression of the molecule in the development pipeline.

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“…Also there were only few reports available on the concomitant crystallization of metastable Form‐II polymorph of vanillin at specific growth conditions in the presence of stable Form‐I. [ 16–18 ] Besides no reports are available on the intermolecular investigation of vanillin polymorphs.…”

Section: Introductionmentioning

confidence: 99%

Hirshfeld Surface Analysis of Stable and Metastable Polymorphs of Vanillin

Supriya

Srinivasan

2020

Crystal Research and Technology

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The intermolecular interactions and the properties of voids present in the stable Form‐I and metastable Form‐II polymorphs of vanillin, a significant pharmaceutical and food material, are investigated through Hirshfeld surface analysis. Form‐I and Form‐II polymorphs of vanillin are separately grown through a template‐induced heterogeneous nucleation process from aqueous solution in the absence and presence of nickel foam as template and their structural parameters are obtained through single crystal X‐ray diffraction (SCXRD) analysis. With this SCXRD data as input, the intermolecular interactions within the grown polymorphs are analyzed by Hirshfeld surface analysis with detailed finger print plot and the area, volume, and percentage of voids present inside the polymorphic structures are identified through the isosurface of the spherical promolecular electron density. The 2D finger print analysis of each of the polymorphs reveals that besides the (H─H) interaction, the (O─H) interaction contributes more to the generation of polymorphs. Furthermore the percentage of volume occupied by the voids in the Form‐I and Form‐II are found to be 11.55% and 19.92%, respectively.

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The role of ultrasound in controlling the liquid-liquid phase separation and nucleation of vanillin polymorphs I and II

Cited by 26 publications

References 19 publications

Sonocrystallisation: Observations, theories and guidelines

Sonocrystallisation: Observations, theories and guidelines

A Pathway to First Crystals for Substances Prone to Liquid‐Liquid Phase Separation

Hirshfeld Surface Analysis of Stable and Metastable Polymorphs of Vanillin

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