The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Amin, Ruhul; Quispe, Cristina; Docea, Anca Oana; Ydyrys, Alibek; Kulbayeva, Marzhan; Daştan, Sevgi Durna; Calina, Daniela; Sharifi‐Rad, Javad

doi:10.1016/j.neuint.2022.105376

Cited by 29 publications

(15 citation statements)

References 74 publications

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“…One of the major mediators of neuroinflammation in PD is TNF-α, which, similar to other cytokines, is produced by activated microglia and astrocytes. Although TNF-α can be neuroprotective in the brain, long-term neuroinflammation and TNF-α release can be harmful, having a neurotoxic role that leads to death of oligodendrocytes, astrocytes, and neurons and, therefore, is associated with neurodegeneration [12,13]. Moreover, a sustained inflammation accompanied by systemic activation of the immune system is observed in PD patients, with changes in the periphery, specifically in cells of the innate immune system, e.g., monocytes, and the adaptive immune system, such as T lymphocytes [14].…”

Section: Introductionmentioning

confidence: 99%

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity

Xiromerisiou

Marogianni

Lampropoulos

et al. 2022

IJMS

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One of the major mediators of neuroinflammation in PD is tumour necrosis factor alpha (TNF-α), which, similar to other cytokines, is produced by activated microglia and astrocytes. Although TNF-α can be neuroprotective in the brain, long-term neuroinflammation and TNF release can be harmful, having a neurotoxic role that leads to death of oligodendrocytes, astrocytes, and neurons and, therefore, is associated with neurodegeneration. Apart from cytokines, a wide family of molecules with homologous structures, namely chemokines, play a key role in neuro-inflammation by drawing cytotoxic T-lymphocytes and activating microglia. The objective of the current study was to examine the levels of the serum TNF-α and CCL2 (Chemokine (C-C motif) ligand 2), also known as MCP-1 (Monocyte Chemoattractant Protein-1), in PD patients compared with healthy controls. We also investigated the associations between the serum levels of these two inflammatory mediators and a number of clinical symptoms, in particular, disease severity and cognition. Such an assessment may point to their prognostic value and provide some treatment hints. PD patients with advanced stage on the Hoehn–Yahr scale showed an increase in TNF-α levels compared with PD patients with stages 1 and 2 (p = 0.01). Additionally, the UPDRS score was significantly associated with TNF-α levels. CCL2 levels, however, showed no significant associations.

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Section: Introductionmentioning

confidence: 99%

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity

Xiromerisiou

Marogianni

Lampropoulos

et al. 2022

IJMS

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“…The brain is one of the most important organs of the body, which allows the evolution of the human being and species [17,111,[151][152][153]. Brain functions are influenced by poor nutrition, stress and lack of movement, but also by natural cellular oxidation processes [19,106,[154][155][156][157].…”

Section: Neuroprotectivementioning

confidence: 99%

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

et al. 2023

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Paeoniaemodi Wall. ex Royle is commonly known as Himalayan paeony has great importance as a food and medicine. The practice of Paeoniaemodi Wall. ex Royle is very ancient and it is conventionally used for a wide range of illnesses in the folk system of medicine because of its wide beneficial phytochemical profile. The main purpose of the current review was the synthesis of recent data on botany, ethnopharmacology, phytochemistry and potential pharmacological mechanisms of action of Paeoniaemodi Wall. ex Royle, thus offering new prospects for the development of new adjuvant natural therapies. Using scientific databases such as PubMed/MedLine, Scopus, Web of Science, ScienceDirect, Google Scholar, Springer, and Wiley, a comprehensive literature search was performed for Paeoniaemodi Wall. ex Royle. For searching, we used the next MeSH terms: “Biological Product/isolation and purification”, “Biological Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. The results of the most recent studies were analyzed and the most important data were summarized in tables and figures. Phytochemical research of Paeoniaemodi Wall. ex Royle has led to the isolation of triterpenes, monoterpenes, phenolic acids, fatty acids, organic compounds, steroids, free radicals and some other classes of primary metabolites. In addition, diverse pharmacological activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase and beta-glucuronidase inhibiting activity, radical scavenging activity, phytotoxic and insecticidal activities have been reported for Paeoniaemodi Wall. ex Royle. Different bioactive compounds of Paeoniaemodi Wall. ex Royle has proven their therapeutic potential in modern pharmacological and biomedical research to cure numerous gastrointestinal and nervous disorders. In future, further in vitro and in vivo therapeutic studies are required to identify new mechanisms of action, pharmacokinetics studies, and new pharmaceutical formulations for target transport and possible interaction with allopathic drugs. Also, new research regarding quality evaluation, toxicity and safety data in humans is needed.

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“…Contrary to this, degeneration of neuromuscular junctions caused by severe cytological stress of motoneurons is suppressed in egr mutant animals or upon depletion of Egr in the glia, suggesting that in the context of nonresolved axonal insult, Egr contributes to neuromuscular degeneration [18]. This is reminiscent of mammalian TNF that not only has a neuroprotective function in the glia but also causes neuroinflammation and degeneration in diseases such as Alzheimer's and Parkinson's disease [24]. In addition to its cytoprotective and cytotoxic properties, studies from the 80s noted a correlation between TNF titers and sleep patterns and established the role of TNF in promoting sleep [25,26].…”

Section: Physiological and Pathophysiological Functions Of Egrmentioning

confidence: 99%

DrosophilaTNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis

Colombani,

Andersen

2023

FEBS Letters

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Tumor necrosis factor (TNF)‐α is a highly conserved pro‐inflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF‐TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF‐mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contributes to its anti‐tumor and tumor promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity‐ and cancer‐associated metabolic diseases has provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.

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The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Cited by 29 publications

References 74 publications

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

DrosophilaTNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis

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