The role of tumor invasion into the mandible of oral squamous cell carcinoma

Abstract

If bone invasion is identified histologically in a resected specimen, the prognosis is not worsened and additional surgery need not be undertaken in adequately resected margins. Although the mandible should be preserved if feasible, the choice of treatment should always provide safe resection margin. The high rates of unsuspected bone invasion found in this study should be kept in mind in patients with OSCC close to the mandible.

Correlation between degree of bone invasion and prognosis in carcinoma of the mandibular gingiva: Soft tissue classification based on UICC classification

“…Moreover, it is easy to decide surgical margin in 14 bone because of form of mandible. Mucke et al [11] reported that cancer recurrence was 15 associated with OS, which is consistent with the current study. It is important to control local 16 recurrence from the adjacent soft tissue rather than the bone.…”

“…reported that invasion of the mandibular bone was not related to outcomes among patients 10 with carcinoma of the mandibular gingiva [11,[23][24][25][26]. In general, superficial extent of 11 carcinoma in soft tissue is broader than that in bone from CT or MRI images.…”

“…Muvke et al [11] identified bone invasion by postoperative histopathological analysis 9 in 15.5% of patients in whom bone invasion could not be diagnosed preoperatively. To further explore local recurrence, we evaluated the specific regions of recurrence.…”

Epidemiological characterization of oral cancer. Literature review.

“…The most common type is the SCC by invasion, which usually comes from the gingival and alveolar mucosae 40 , that invades the bone by direct extension or by perineural invasion. The incidence of invasion varies between 12 to 56% 41 . They show a high rate of recurrence (61.9%) and a low survival rate at 5 years (25.8%) 42 .…”

Surgical Decision Making in Oral Mucosal Melanoma with Lymphadenopathy: Review of Literature

“…16,17 The surgical resection within oral cavity remains problematic because wide resection margins require also reconstruction technique after tumor ablation to avoid mutilation, functional impairment and poor quality of life. [18][19][20] Regional lymph nodes are the most common sites of metastases for all melanomas. Palpable lymph nodes in neck or fixed to the adjacent tissues should be suspicious for metastases.…”