“…42,59,63 In a rat model of rotator cuff repair, the addition of TGFb3 resulted in improved mechanical properties compared with those treated with TGF-b1. 59,60,73 The exogenous application of TGF-b1, combined with suppression of TGF-b2 and TGF-b3, resulted in an increased crosssectional area of the repair tissue. This abundant scar, however, produced a mechanically inferior repair, highlighting the observation that abundant scar formation does not necessarily correlate with a biomechanically and Figure 2 Schematic diagram illustrates the manner in which early tendinopathy may arise due to inflammation.…”