The role of tranexamic acid in decreasing intraoperative and postoperative blood loss in patients undergoing total hip replacement

Abstract

We investigated 60 patients undergoing Total hip arthropasty in a prospective, interventional and randomized study. Here, patients were divided alternatively into two groups of 30 patients each, in group A and group B. Group A will receive intravenous infusion of tranexamic acid at dose of 15mg/kg and same will be given 3hrs after the first dose, while in group B no drug will be given. Direct and Indirect blood loss is calculated. Hence, direct blood loss is less (p value=0.000) in tranexamic group compared to control group i.e988 vs 1295 ml. Indirect blood loss, is also significantly lower in patients receiving drug as compared to placebo group. i.e (1018.87±160.76 vs 1335.2±194.4 ml) None of the patient in our study in either group developed any complication. In conclusion, we found Tranexamic acid, administrated before surgical incision, to be efficient in reducing Direct and Indirect blood loss during Total hip arthroplasty.Thus, we conclude that Tranexamic acid administration is an effective, safe and cheap method for reducing total blood loss, drain output, and hemoglobin drop without any increase in thromboembolic complications.