The role of traditional herbal medicine for ischemic stroke: from bench to clinic—A critical review

Hao, Dan-Li; Li, Jiameng; Xie, Ran; Huo, Hai-Ru; Xiong, Xingjiang; Shi, Feng; Wang, Pengqian

doi:10.1016/j.phymed.2022.154609

Cited by 8 publications

(5 citation statements)

References 277 publications

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“…When used in stroke rehabilitation, the combination of TCM and Western medicine has been shown to be more effective than Western medicine alone, as it can improve neurological deficits, reduce adverse reactions, and lead to better patient outcomes. This also highlights the superior efficacy of acupuncture when combined with Western medicine ( Zhong L. L. et al, 2022 ; Hao et al, 2023 ). Traditional Chinese herbal medicine (TCHM) has been used as a single or adjuvant treatment for stroke, working through a variety of mechanisms such as anti-inflammation, anti-oxidative stress, anti-apoptosis, regulation of BBB, inhibition of platelet activation, and promotion of neurogenesis and angiogenesis.…”

Section: The Difference and Combination Of Traditional Chinese And We...mentioning

confidence: 89%

“…Traditional Chinese herbal medicine (TCHM) has been used as a single or adjuvant treatment for stroke, working through a variety of mechanisms such as anti-inflammation, anti-oxidative stress, anti-apoptosis, regulation of BBB, inhibition of platelet activation, and promotion of neurogenesis and angiogenesis. TCHM provides a valuable resource for the development of therapeutic drugs to treat stroke and for the discovery of more effective and safer combination therapy or individual treatment methods ( Hao et al, 2023 ).…”

Section: The Difference and Combination Of Traditional Chinese And We...mentioning

confidence: 99%

“…TCM is a vast treasure trove, and there are many potential drugs that can be developed from it. Therefore, in the future, efforts should be directed towards excavating and developing the TCM treasure trove ( Duan T. et al, 2022 ; Feng et al, 2022 ; Zhong L. L. et al, 2022 ; Hao et al, 2023 ). Additionally, it is essential to focus on the development of TCM placebo and randomized controlled trials to improve the credibility of TCM for stroke treatment.…”

Section: Problems and Prospectsmentioning

confidence: 99%

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A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine

Jin

2023

Front. Neurosci.

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This review provides insight into the complex network of signaling pathways and mechanisms involved in stroke pathophysiology. It summarizes the historical progress of stroke-related signaling pathways, identifying potential interactions between them and emphasizing that stroke is a complex network disease. Of particular interest are the Hippo signaling pathway and ferroptosis signaling pathway, which remain understudied areas of research, and are therefore a focus of the review. The involvement of multiple signaling pathways, including Sonic Hedgehog (SHH), nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE), hypoxia-inducible factor-1α (HIF-1α), PI3K/AKT, JAK/STAT, and AMPK in pathophysiological mechanisms such as oxidative stress and apoptosis, highlights the complexity of stroke. The review also delves into the details of traditional Chinese medicine (TCM) therapies such as Rehmanniae and Astragalus, providing an analysis of the recent status of western medicine in the treatment of stroke and the advantages and disadvantages of TCM and western medicine in stroke treatment. The review proposes that since stroke is a network disease, TCM has the potential and advantages of a multi-target and multi-pathway mechanism of action in the treatment of stroke. Therefore, it is suggested that future research should explore more treasures of TCM and develop new therapies from the perspective of stroke as a network disease.

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Section: The Difference and Combination Of Traditional Chinese And We...mentioning

confidence: 89%

Section: The Difference and Combination Of Traditional Chinese And We...mentioning

confidence: 99%

Section: Problems and Prospectsmentioning

confidence: 99%

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A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine

Jin

2023

Front. Neurosci.

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“…Atractylenolide III in Atractylodes macrocephala Koidz ameliorates cerebral ischemic injury and neuroinflammation associated with inhibiting JAK2/STAT3/Drp1-dependent mitochondrial fission in microglia ( Zhou et al, 2019 ). Several medicinal materials and components of GPW have been reported to improve cerebral ischemia reperfusion injury ( Hao et al, 2023 ). These results suggest that GPW, as a clinical prescription of traditional Chinese medicine, may be effective in treating cerebral ischemia-reperfusion injury, but the underlying pharmacological mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological effects and target analysis of Guipi wan in the treatment of cerebral ischemia-reperfusion injury

Zhang,

Luo,

Guo

et al. 2024

Front. Pharmacol.

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Guipi wan (GPW) is a traditional Chinese medicine commonly used in clinical practice, typically to treat neurological diseases such as neurasthenia and traumatic brain injury. It may have positive effects on cerebral ischemia‒reperfusion injury (cI/R). This study aimed to assess the effects of GPW in a mouse model of cI/R and find its possible targets. C57BL/6J mice were used to establish the cI/R model, and the laser speckle doppler was used to determine the success of the model. GPW was administered intragastrically for 7 days, brain tissue sections were stained with TTC, HE, and TUNEL, Western blot assay was performed to detect the effect of apoptosis-related proteins. Furthermore, we screened active ingredients from the TCM Database and constructed a compound‒target network using the Cytoscape 3.8.0 software. Moreover, we employed protein‒protein interaction and component‒target‒pathway network analyses to determine the potential components of GPW and its target genes, the key target was verified through molecular docking. Finally, we detected the influence of the downstream signaling pathway of the target through Western blot. The results showed that GPW decreased the cerebral infarction area, neurological function scores, and neuronal apoptosis in mice by regulating PI3K/AKT signaling pathway. Network analysis indicated that gamma-aminobutyric acid B receptor 1 (GABBR1) might be a potential target for the treatment of cI/R. Molecular docking indicated that 9 active components in GPW could bind to GABBR1 with desirable binding energy. This study represented the demonstratable effect of GPW in the treatment of cI/R injury and suggested GABBR1 as a potential target using network analysis.

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“…Additionally, rt-PA administration can lead to worsening inflammation, which is not conducive to stroke control and recovery [ 15 ]. Traditional herbal medicine (THM) has been demonstrated to be able to reduce early events of stroke, reduce the recurrence rate, and improve neurologic deficits [ 16 , 17 ]. Although various of mechanisms [ 18 , 19 ] have been proposed, it is still unclear why THMs have effects on IS treatment.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Pharmacological Mechanisms of Total Flavonoids from Eucommia ulmoides Oliver Leaves for Ischemic Stroke Protection

Qin,

Chen,

Wang

et al. 2024

IJMS

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The aim of this study was to explore how the total flavonoids from Eucommia ulmoides leaves (EULs) regulate ischemia-induced nerve damage, as well as the protective effects mediated by oxidative stress. The cell survival rate was significantly improved compared to the ischemic group (p < 0.05) after treatment with the total flavonoids of EULs. The levels of reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) decreased, while catalase (CAT) and glutathione (GSH) increased, indicating that the total flavonoids of EULs can significantly alleviate neurological damage caused by ischemic stroke by inhibiting oxidative stress (p < 0.01). The mRNA expression level of VEGF increased (p < 0.01), which was consistent with the protein expression results. Meanwhile, the protein expression of ERK and CCND1 increased (p < 0.01), suggesting that the total flavonoids of EULs could protect PC12 cells from ischemic injury via VEGF-related pathways. MCAO rat models indicated that the total flavonoids of EULs could reduce brain ischemia–reperfusion injury. In conclusion, this study demonstrates the potential mechanisms of the total flavonoids of EULs in treating ischemic stroke and their potential therapeutic effects in reducing ischemic injury, which provides useful information for ischemic stroke drug discovery.

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The role of traditional herbal medicine for ischemic stroke: from bench to clinic—A critical review

Cited by 8 publications

References 277 publications

A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine

A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine

Pharmacological effects and target analysis of Guipi wan in the treatment of cerebral ischemia-reperfusion injury

Investigating the Pharmacological Mechanisms of Total Flavonoids from Eucommia ulmoides Oliver Leaves for Ischemic Stroke Protection

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