The role of timely measurement of galectin-3, NT-proBNP, cystatin C and hsTnT in predicting prognosis and heart function after heart transplantation

Franeková, Janka; Hošková, Lenka; Sečník, Peter; Pazderník, Michal; Kotrbatá, Markéta; Kubíček, Zdenĕk; Jabor, Antonı́n

doi:10.1515/cclm-2014-1218

Cited by 19 publications

(16 citation statements)

References 6 publications

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“…A group of 107 consecutive patients was evaluated before and after HTx. This group was previously described by Franekova et al 9 Briefly, 63 patients had idiopathic dilated cardiomyopathy, 41 patients had end-stage ischemic heart disease, two patients had congenital heart disease, and one patient had restrictive cardiomyopathy. All patients received induction immunosuppression with thymoglobulin at a dose of 1.25 mg/kg of body weight during surgery.…”

Section: Patientsmentioning

confidence: 99%

Serial measurement of presepsin, procalcitonin, and C‐reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Franeková

Sečník

Lavríková

et al. 2016

Clinical Transplantation

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Differentiation between systemic inflammatory response syndrome and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aimed to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT, and CRP were measured in 107 patients serially for up to 10 days following HTx. Time responses of biomarkers were evaluated for both noninfected (n=91) and infected (n=16) patients. Areas under the concentration curve differed in the two groups of patients for presepsin (P<.001), PCT (P<.005), and CRP (P<.001). The effect of time and infection was significant for all three biomarkers (P<.05 all). In contrast to PCT, presepsin was not influenced by ATG administration. More than 25% of noninfected patients had PCT above 42 μg/L on the first day, and the peak concentration of CRP in infected patients was reached on the third post-transplant day (median 135 mg/L). Presepsin seems to be as valuable a biomarker as PCT or CRP in the evaluation of infectious complications in patients after HTx.

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Section: Patientsmentioning

confidence: 99%

Serial measurement of presepsin, procalcitonin, and C‐reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Franeková

Sečník

Lavríková

et al. 2016

Clinical Transplantation

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“…Of note, kidney function did not differ significantly between our CAV and control groups; however, the CST3 levels were significantly higher in our CAV patients suggesting non‐renal mechanisms involved in its upregulation. Franeková and colleagues have shown higher levels of CST3 to predict worse prognosis in heart transplant patients, but the incidence of CAV was not directly assessed . Similarly, the histone cluster 1 H3 family member A (HIST1H3A) protein that is linked to complement and macrophage activation was also elevated in our CAV patients .…”

Section: Discussionmentioning

confidence: 70%

“…Inflammatory markers such as C‐reactive protein, tumor necrosis factor‐α (TNF‐α), interleukin‐1B (IL‐1B), and uric acid are increased in subjects with CAV . In addition to a pro‐inflammatory function, cystatin C (CST3) has been shown to be a robust measure of glomerular filtration rate .…”

Section: Discussionmentioning

confidence: 99%

Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics

Almufleh

Zhang

Mielniczuk

et al. 2019

Clinical Transplantation

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Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. Non-invasive evaluation is challenging, and currently, there is no validated biomarker for CAV diagnosis or prognostication. To identify potential candidate CAV biomarkers, we utilized the Slow Off-rate Modified Aptamer (SOMAscan) assay, which evaluates over 1000 serum proteins, including many relevant to biological pathways in CAV. We evaluated three heart transplant patient groups according to angiographic ISHLT CAV grade: CAV 1-2 (mild-moderate CAV), CAV 3 (severe CAV), and CAV 0 (normal control). SOMAscan assays were performed and proteins quantitated.Comparisons of proteins between study groups were performed using one-way ANOVA (false discovery rate q-value < 0.10). Thirty-one patients (12 mild-moderate CAV, 9 severe CAV, 10 controls) were included: 81% male, median age 57 years and median 1.1 years post-transplant. Compared to controls, patients with mild-moderate CAV had similar characteristics, while patients with severe CAV had longer time from transplant and increased allosensitization. Statistical/bioinformatics analysis identified 14 novel biomarkers for CAV, including 4 specific for mild-moderate CAV.These proteins demonstrated important actions including apoptosis, inflammation, and platelet/coagulation activation. Upon preliminary receiver operating characteristics curve analysis, our protein biomarkers showed moderate-to-high discriminative ability for CAV (area under curve: 0.72 to 0.94). These candidate biomarkers are being validated in prospective studies. K E Y W O R D Saptamer proteomic profiling, cardiac allograft vasculopathy, serum biomarkers

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“…Острое повреждение почек является одним из самых частых осложнений при трансплантации сердца, оказывающим существенное влияние не только на конечные результаты лечения, но и на так тику ведения реципиентов сердечного транспланта та. Цистатин С наряду с другими современными маркерами почечного повреждения рассматрива ется в качестве перспективного показателя ранней диагностики данного осложнения [7]. Имеются сообщения о повышении сывороточных концент раций цистатина С после трансплантации сердца, предшествующем повышению традиционных мар керов почечной функции, таких как креатинин, и являющемся достоверным предиктором развития ОПП [6].…”

Section: Discussionunclassified

Cystatin C in the diagnostics of acute kidney injury after heart transplantation

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Поз

Попцов

et al. 2017

RJTAO

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Aim. To examine the assumption that significant concentrations of cystatin C in urine are the manifestation of the tubular necrosis and, respectively, the severity of kidney damage after heart transplantation (HTx).Materials and methods. In this study we evaluated 33 heart recipients (6 women and 27 men, aged from 24 to 68 years old) who had risk factors of acute kidney injury: serum creatinine level >113 μmol/l and/or mechanical circulatory support requirement (20 patients, in 14 cases before HTx). Cystatin C concentration in serum and in urine was measured by DyaSis particle-enhanced immunoturbidimetric assay test «Cystatin C FS».Results. Recipients were divided into two groups according to the levels of cystatinuria. In the group with the significant (more than 0.18 mg/l) urinary cystatin C concentrations the requirement of renal replacement therapy (RRT) was 2.5-fold higher, and the mean duration of RRT was more than 10-fold longer. In 2 patients with the significant cystatinuria acute kidney injury (AKI) has transformed into end-stage renal disease (ESRD).Conclusion. Due to data obtained we may suppose that significant concentrations of cystatin C in urine are the marker of the tubular necrosis with the prolonged RRT requirement. Further studies are needed to justify this relationship.

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The role of timely measurement of galectin-3, NT-proBNP, cystatin C and hsTnT in predicting prognosis and heart function after heart transplantation

Abstract: Cystatin C and hsTnT measured 10 days after HTx can provide prognostic information on survival and galectin-3 measured at the same time may display a relationship to heart function assessed 1 year after HTx. Further study should be carried out in a large cohort of patients.

Cited by 19 publications

References 6 publications

Serial measurement of presepsin, procalcitonin, and C‐reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Serial measurement of presepsin, procalcitonin, and C‐reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation

Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics

Cystatin C in the diagnostics of acute kidney injury after heart transplantation

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