The rôle of time in reducing gingival overgrowth in heart‐transplanted patients following cyclosporin therapy

Abstract

The results suggest that GO necessarily develops in responders within 6 months from heart transplantation and in most subjects may be a time-related side-effect probably due to a progressive reduction in the sensitivity of the periodontum to CsA.

Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients

“…These data suggest that gingival inflammation may be an important component of enhanced gingival volume in CsA responders, but it is in no way the only factor responsible for this side effect. This again confirms previous data reported in one of our recent studies, which showed that the short-term effectiveness of scaling on gingivitis is not necessarily strictly related to a significant improvement in GO [12].…”

“…Gingival overgrowth (GO) has been described as a frequent side effect in heart and renal transplant patients during immunosuppressive therapy with cyclosporine A (CsA) [12,18].…”

A systematic review of the effectiveness of oral health promotion activities among patients with cardiovascular disease

“…plaque, gingival health, and oral hygiene) was an oral health promotion outcome in 7 of 8 studies [52][53][54][55][56][57], while changes in systemic blood marker levels (e.g. C-reactive protein, IL-6) were an outcome in 5 studies [52,54,56,58,59].…”

“…Both studies [53,55] on heart transplant patients used periodontal health as oral health promotion outcomes. In a randomized split-mouth study, Montebugnoli et al [53] demonstrated a significant decrease in BOP and PI 1 month following oral hygiene instructions, scaling, and root planing, regardless of whether a placebo or metronidazole gel was used as an adjunct.…”

“…In a single group pre-/post-intervention study [55], scaling was provided 9 months following heart transplantation, and oral hygiene instructions were reinforced every 6 months. A significant reduction in PI and GI was observed at 12, 24, 36, and 48 months compared to baseline readings (6 months following heart transplantation).…”