2005
DOI: 10.1016/j.bcp.2005.02.023
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The role of thioredoxin reductase activity in selenium-induced cytotoxicity

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Cited by 41 publications
(29 citation statements)
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“…As for the roles of selenium-containing proteins in the selective cytotoxicity of selenium, the effects of thioredoxin reductase 1 (TrxR1) on selenium cytotoxicity, one selenoprotein that is frequently up-regulated in cancer cells and functions as one of the major redox regulators in mammalian cells (reviewed In Ref. [8]), have been extensively investigated previously [7,8,20,51,55,56]. Overexpression of this enzyme has been shown to protect cells from selenite-induced cytotoxicity [55]; in contrast, reduction of TrxR1 enhances selenite toxicity in cancer cells by elevating extracellular GSH through a mechanism that is independent of thioredoxin [56].…”
Section: Discussionmentioning
confidence: 99%
“…As for the roles of selenium-containing proteins in the selective cytotoxicity of selenium, the effects of thioredoxin reductase 1 (TrxR1) on selenium cytotoxicity, one selenoprotein that is frequently up-regulated in cancer cells and functions as one of the major redox regulators in mammalian cells (reviewed In Ref. [8]), have been extensively investigated previously [7,8,20,51,55,56]. Overexpression of this enzyme has been shown to protect cells from selenite-induced cytotoxicity [55]; in contrast, reduction of TrxR1 enhances selenite toxicity in cancer cells by elevating extracellular GSH through a mechanism that is independent of thioredoxin [56].…”
Section: Discussionmentioning
confidence: 99%
“…The effects of long-term selenium exposure in rats are determined by a complex combination of the above system of antioxidant parameters [13,14]. Antiproliferative and apoptotic effects of the selenium depend on the amount of …”
Section: Biochemical Parameters Of Liver Tissuementioning
confidence: 99%
“…It is known that inhibition of TrxR results in enhanced selenite cytotoxicity and that cells overexpressing TrxR1 are significantly more resistant to selenite cytotoxicity than control cells. 85,86 TrxR1 has been shown to be upregulated in various cancer cells; thus, cancer cells are likely to be more resistant than normal cells to Se cytotoxicity. Drug-resistant tumor cells with high intracellular GSH exhibit a high degree of sensitivity to selenite cytotoxicity, whereas normal cells with high intracellular GSH would be more sensitive to Se cytotoxicity than some types of cancer cells with low intracellular GSH.…”
Section: Se-mediated Cytotoxicity and Cancer Preventionmentioning
confidence: 99%