The role of thioredoxin reductase activity in selenium-induced cytotoxicity

Madeja, Zbigniew; Sroka, Jolanta; Nyström, Christina; Björkhem‐Bergman, Linda; Nordman, Tomas; Damdimopoulos, Anastasios; Nalvarte, Ivan; Eriksson, Lennart C.; Spyrou, Giannis; Olsson, Jerker M.; Björnstedt, Mikael

doi:10.1016/j.bcp.2005.02.023

Cited by 40 publications

(26 citation statements)

References 25 publications

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“…As for the roles of selenium-containing proteins in the selective cytotoxicity of selenium, the effects of thioredoxin reductase 1 (TrxR1) on selenium cytotoxicity, one selenoprotein that is frequently up-regulated in cancer cells and functions as one of the major redox regulators in mammalian cells (reviewed In Ref. [8]), have been extensively investigated previously [7,8,20,51,55,56]. Overexpression of this enzyme has been shown to protect cells from selenite-induced cytotoxicity [55]; in contrast, reduction of TrxR1 enhances selenite toxicity in cancer cells by elevating extracellular GSH through a mechanism that is independent of thioredoxin [56].…”

Section: Discussionmentioning

confidence: 99%

Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

Wang

Fang

Huang

et al. 2015

Free Radical Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

Wang

Fang

Huang

et al. 2015

Free Radical Biology and Medicine

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“…The effects of long-term selenium exposure in rats are determined by a complex combination of the above system of antioxidant parameters [13,14]. Antiproliferative and apoptotic effects of the selenium depend on the amount of …”

Section: Biochemical Parameters Of Liver Tissuementioning

confidence: 99%

Sodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liver

Ayaz

Celik

Aydin

et al. 2006

Diabetes Metab. Res. Rev.

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“…It is known that inhibition of TrxR results in enhanced selenite cytotoxicity and that cells overexpressing TrxR1 are significantly more resistant to selenite cytotoxicity than control cells. 85,86 TrxR1 has been shown to be upregulated in various cancer cells; thus, cancer cells are likely to be more resistant than normal cells to Se cytotoxicity. Drug-resistant tumor cells with high intracellular GSH exhibit a high degree of sensitivity to selenite cytotoxicity, whereas normal cells with high intracellular GSH would be more sensitive to Se cytotoxicity than some types of cancer cells with low intracellular GSH.…”

Section: Se-mediated Cytotoxicity and Cancer Preventionmentioning

confidence: 99%

Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention

Zhang¹

2012

IJN

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Chemoprevention that impedes one or more steps in carcinogenesis, via long-term administration of naturally occurring or synthetic compounds, is widely considered to be a crucial strategy for cancer control. Selenium (Se) has chemopreventive effects, but its application is limited due to a low therapeutic index as shown in numerous animal experiments. In contrast to Se, which was known for its toxicity prior to the discovery of its beneficial effects, the natural compound epigallocatechin-3-gallate (EGCG) was originally considered to be nontoxic. Due to its preventive effects on many types of cancer in various animal models, EGCG has been regarded as a prime example of a promising chemopreventive agent without major toxicity concerns. However, very recently, evidence has accumulated showing that efficacious doses of EGCG used in health promotion may not be far from its toxic dose level. Therefore, both Se and EGCG need to be modified by novel pharmaceutical technologies to attain enhanced efficacy and/or reduced toxicity. Nanotechnology may be one of these technologies. In support of this hypothesis, the characteristics of polylactic acid and polyethylene glycol-encapsulated nano-EGCG and elemental Se nanoparticles dispersed by bovine serum albumin are reviewed in this article. Encapsulation of EGCG to form nano-EGCG leads to its enhanced stability in plasma and remarkably superior chemopreventive effects, with more than tenfold dose advantages in inducing apoptosis and inhibition of both angiogenesis and tumor growth. Se at nanoparticle size ("Nano-Se"), compared with Se compounds commonly used in dietary supplements, has significantly lower toxicity, without compromising its ability to upregulate selenoenzymes at nutritional levels and induce phase II enzymes at supranutritional levels.

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The role of thioredoxin reductase activity in selenium-induced cytotoxicity

Cited by 40 publications

References 25 publications

Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

Sodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liver

Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention

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