2015
DOI: 10.1016/j.freeradbiomed.2014.11.015
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Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

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Cited by 30 publications
(26 citation statements)
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References 59 publications
(156 reference statements)
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“…This finding suggests that p21 protein is likely to be a crucial player in SELENBP1-mediated cancer cell growth inhibition. To verify this notion, we established stable transfectants expressing HA-tagged SELENBP1 protein in human colon cancer HCT116 wild-type cells (HCT116 WT) and p21 knockout cells (HCT116 p21 −/− ), in both of which endogenous protein levels of SELENBP1 were undetectable [30]. As expected, overexpression of SELENBP1 consistently stimulated p21 protein expression and further significantly inhibited anchorage-independent cell growth in HCT116 WT cells ( Fig.…”
Section: Induction Of P21 Protein Is Crucial For Selenbp1-mediated G mentioning
confidence: 64%
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“…This finding suggests that p21 protein is likely to be a crucial player in SELENBP1-mediated cancer cell growth inhibition. To verify this notion, we established stable transfectants expressing HA-tagged SELENBP1 protein in human colon cancer HCT116 wild-type cells (HCT116 WT) and p21 knockout cells (HCT116 p21 −/− ), in both of which endogenous protein levels of SELENBP1 were undetectable [30]. As expected, overexpression of SELENBP1 consistently stimulated p21 protein expression and further significantly inhibited anchorage-independent cell growth in HCT116 WT cells ( Fig.…”
Section: Induction Of P21 Protein Is Crucial For Selenbp1-mediated G mentioning
confidence: 64%
“…As previously described [28,29], UMUC3 and T24T cell lines were authenticated by Genetica DNA Laboratories (Burlington, NC, USA). The constructs encoding human HA-tagged SELENBP1 (HA-SELENBP1) [30] or dominant-negative form of c-Jun (TAM67) [31] were previously described. The plasmid encoding dominantnegative STAT1 (DN-STAT1 Y701F) and its control empty vector (pEGFP-C1) were gifts from Alan Perantoni [33].…”
Section: Cell Lines Cell Culture and Plasmidsmentioning
confidence: 99%
“…SBP1 has been demonstrated to play a crucial role in controlling the oxidation/reduction and redox homeostasis in a number of physiological processes [51]. A number of studies have demonstrated that SBP1 expression is reduced in a variety of cancers, and that reduced expression is correlated with poor prognosis in cancer patients [52]. SBP1 was identified by our laboratory as a protein that is carbonylated in sham-irradiated liver tissue but has reduced carbonylation following radiation exposure [25], in agreement with our current findings in lung tissue.…”
Section: Resultsmentioning
confidence: 99%
“…SBP1 knockdown may have a role in helping the efflux of GSH, leading to an increase in the steady-state levels of intracellular ROS. 120 Se has been shown to be a very powerful protector against cytotoxicity and genotoxicity caused by OS (ultraviolet A [UVA] or H 2 O 2 ) but not by 121 The antitumor effects of Se are connected to its ability to induce apoptosis, and to modulate Ca 2+ influx through ion channels. Recently, the modulatory effect of Se on apoptosis, OS, and intracellular Ca 2+ through transient receptor potential channels has been reported.…”
Section: Se Implicationmentioning
confidence: 99%