Author's summary
Dronedarone can attenuate left ventricular hypertrophy of mice. However, the underlying mechanism of dronedarone in myocardial hypertrophy (MH) is unknown. Our results indicated that dronedarone increased sirtuin 1 (SIRT1) expression. Further, SIRT1 mediated deacetylation of forkhead box O3 (FOXO3) to upregulate FOXO3 expression and FOXO3 interacted with protein kinase inhibitor alpha (PKIA) promoter to elevate PKIA expression. Dronedarone suppressed angiotensin II-induced cell hypertrophy through upregulating SIRT1/FOXO3/PKIA axis. The research provides more evidences for dronedarone against MH. myocardial hypertrophy.