Dronedarone Attenuates Ang II-Induced Myocardial Hypertrophy Through Regulating SIRT1/FOXO3/PKIA Axis

Abstract

Author's summary Dronedarone can attenuate left ventricular hypertrophy of mice. However, the underlying mechanism of dronedarone in myocardial hypertrophy (MH) is unknown. Our results indicated that dronedarone increased sirtuin 1 (SIRT1) expression. Further, SIRT1 mediated deacetylation of forkhead box O3 (FOXO3) to upregulate FOXO3 expression and FOXO3 interacted with protein kinase inhibitor alpha (PKIA) promoter to elevate PKIA expression. Dronedarone suppressed angiotensin II-induced cell hypertrophy through upregulating SIRT1/FOXO3/PKIA axis. The research provides more evidences for dronedarone against MH. myocardial hypertrophy.