The Role of the Stress Factor in Mediating the Genetic Predisposition to Stroke of the Background of Hypertensive Disease

Abstract

Objectives. To study the interaction of polymorphic markers for matrix metalloproteinases (MMP) and chronic stress on formation of stroke on the background of hypertensive disease. Materials and methods. A total of 830 patients were studied: 303 patients with ischemic stroke on the background of hypertensive disease and 527 patients with hypertensive disease without stroke. SNP for metalloproteinases were studied using the real-time polymerase chain reaction. The functional signifi cance and infl uences of polymorphic loci on gene expression were studied using the HaploReg (v4.1) (http://archive.broadinstitute.org) and GTEx-portal (http://gtexportal.org) services. Results and conclusions. An association was found between the GG rs11568818 genotype of the MMP7 gene and a high risk of developing stroke in patients experiencing regular stress (odds ratio (OR) 1.71). The 5A allele and the 5A/5A genotype of rs3025058 of the MMP3 gene had protective effects on development of stroke in people without histories of chronic stress (OR 0.73 and OR 0.60, respectively). The SNP studied here were located in the histone protein H3K4me1 and H3K4me3 region, which is hypersensitive to DNase 1 and binds regulatory proteins and transcription factors, while the polymorphic rs11568818 locus is linked with the level of expression of the MMP7 gene.

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

“…The dataset contains the raw data (supplementary Table), frequencies of alleles and genotypes ( Table 1 ) for three SNPs of two MMP genes (rs1799750 MMP1 , rs3918242 and rs17576 MMP9 ) in Russian patients diagnosed with POAG, EH, and PU. These polymorphisms were previously reported for their association with POAG, EH, and PU ( Table 2 ) [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] . The studied SNPs manifest the regulatory potential ( Table 3 ), which is evidenced by several eQTLs ( Table 4 ) and splicing QTLs ( Table 5 ).…”

Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia

“…The observed inconsistencies could stem from the differences in study designs (e.g., differences in the used covariates, sample sizes, gene–gene and gene-environment interactions, etc.). In addition, the differences in the results might be associated with ethnicity-specific pathogenetic features of the emergence and course of EH 32 – 37 or/and ethnicity-related differences in the genetic structure of the populations 38 , 39 .…”

Recovery Dynamics in Patients with Ischemic Stroke Depending on the Blood Pressure Indicators and Its Variability

“…При поступлении в стационар тяжесть неврологического дефицита по шкале NIHSS находилась в пределах от 3 до 20 баллов, в среднем составляла 12,5 (6,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)6) балла. Распределение пациентов с ишемическим инсультом по баллу NIHSS приведено на рис.…”

“…Тяжелые социальные последствия инсульта и большие экономические затраты побуждают медицинское сообщество к совершенствованию мер профилактики и лечения острого нарушения мозгового кровообращения [1,2], реабилитационных подходов [3][4][5] и прогнозирования последствий острой мозговой катастрофы [6][7][8]. Высокое систолическое артериальное давление (САД) является одним из основных модифицированных факторов риска инсульта, обусловливающих его тяжесть [9][10][11]. Проблема инсульта на фоне артериальной гипертонии (АГ) очень актуальна в России, учитывая, что по данным Минздрава России в 2020 году зарегистрировано 4303 тысячи пациентов с болезнями системы кровообращения по сравнению с 2000 годом, когда их количество составляло 2483 тысячи от всего населения (по данным Федеральной службы государственной статистики за 2020 год, https://rosstat.gov.ru/folder/13721).…”