“…18,20,21,23,24, All of these were reports of simple case-series, with no comparison of testing policies between groups. Eleven studies were in adults, 18,20,21,23,33,[36][37][38]40,45,46 four of the studies were in children, 28,[30][31][32] four were in both adults and children, 27,41,44,47 and in the remainder of the studies the age of the study population was not specified. 24,26,29,34,35,39,42,43,48 Of the 28 studies, all measured abnormality rates, 18 measured impact on clinical management, 18,20,21,27,28,[30][31][32]34,35,[37][38][39][40]42,…”