The Role of the Renin-Angiotensin System in the Control of Blood Pressure and Drinking in the European Eel, Anguilla anguilla

Tierney, Mary L.; Luke, Garry A.; Cramb, Gordon; Hazon, Neil

doi:10.1006/gcen.1995.1130

Cited by 64 publications

(45 citation statements)

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“…As in mammals, the RAS is physiologically relevant in fish, where it is known to participate in fluid volume control and blood pressure regulation (Smith et al 1991, Tierney et al 1995, Bernier et al 1999b, Takei & Tsuchida 2000, Nishimura 2001, Russell et al 2001. While significant inter-species differences exist with respect to the mechanisms for blood pressure regulation by ANG-II (Bernier et al 1999b), plasma [ANG-II] and renin activities have often been reported to be transiently or chronically elevated following transfer to seawater in several euryhaline fish species (Smith et al 1991, Tierney et al 1995, Anderson et al 2006.…”

Section: Introductionmentioning

confidence: 99%

“…While significant inter-species differences exist with respect to the mechanisms for blood pressure regulation by ANG-II (Bernier et al 1999b), plasma [ANG-II] and renin activities have often been reported to be transiently or chronically elevated following transfer to seawater in several euryhaline fish species (Smith et al 1991, Tierney et al 1995, Anderson et al 2006. Consequently, despite the extensive research related to ANG-II and renal salt reabsorption, surprisingly little is known about its potential role in freshwater fish ionic regulation.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Kumai

Bernier

Perry

2013

Journal of Endocrinology

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The contribution of the renin-angiotensin system (RAS) to Na C uptake was investigated in larval zebrafish (Danio rerio). At 4 days post fertilization (dpf), the level of whole-body angiotensin-II (ANG-II) was significantly increased after 1-or 3-h exposure to acidic (pHZ4.0) or ion-poor water (20-fold dilution of Ottawa tapwater), suggesting rapid activation of the RAS. Long-term (24 h) treatment of 3 dpf larvae with ANG-I or ANG-II significantly increased Na C uptake which was accompanied by an increase in mRNA expression of the NaInduction of Na C uptake by exposure to ANG-I was blocked by simultaneously treating larvae with lisinopril (an angiotensin-converting enzyme inhibitor). Acute (2 h) exposure to acidic water or ion-poor water led to significant increase in Na C uptake which was partially blocked by the ANG-II receptor antagonist, telmisartan. Consistent with these data, translational knockdown of renin prevented the stimulation of Na C uptake following exposure to acidic or ion-poor water. The lack of any effects of pharmacological inhibition (using RU486), or knockdown of glucocorticoid receptors on the stimulation of Na C uptake during acute exposure to acidic or ion-poor environments, indicates that the acute effects of RAS occur independently of cortisol signaling. The results of this study demonstrate that the RAS is involved in Na C homeostasis in larval zebrafish. Key Words" angiotensin-II" cortisol " zebrafish " osmoregulation " ion-poor water " acidic water

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Kumai

Bernier

Perry

2013

Journal of Endocrinology

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“…However, since drinking rate is highly variable among species, some freshwater fish drink more than seawater fish (Bentley, 1971). In Anguilla species, it has been recognized that A. japonica is generally a more copious drinker than A. anguilla (Maetz and Skadhauge, 1968;Hirano, 1974;Tierney et al, 1995;Tsuchida and Takei, 1998). A similar difference was also observed in two closely-related elasmobranch species; the Japanese dogfish, Triakis scyllia, exhibits a much higher drinking rate than the European spotted dogfish, Scyliorhinus cannicula (Anderson et al, 2001).…”

Section: Introductionmentioning

confidence: 82%

“…In Anguilla species, it has long been recognized that Japanese eels, A. japonica, adapted to seawater generally drink much more than European eels, A. anguilla (Takei et al, 1988;Tierney et al, 1995). It was initially thought that the difference is due to the difference in the method of measuring the drinking rate, because an esophageal fistula was used for the measurement in Japanese eels while a radioactive tracer was used in European eels.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, it is suggested that the relative importance of angiotensin II in the regulation of drinking and arterial pressure differs depending on the ambient temperature in eels (Tierney et al, 1995;Takei and Tsuchida, 2000). ANP has been shown to affect drinking and arterial pressure profoundly in eels and other teleost fishes (Duff and Olson, 1986;Lee and Malvin, 1987;Tsuchida and Takei, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Ambient Temperature Regulates Drinking and Arterial Pressure in Eels

Takei

Tsukada

2001

Zoological Science

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Effects of dehydration on plasma osmolality, thirst-related behavior, and plasma and brain angiotensin concentrations in Couch's spadefoot toad,Scaphiopus couchii

Johnson

Propper

2000

J. Exp. Zool.

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Under dehydrating conditions, many terrestrial vertebrates species exhibit increases in plasma osmolality and their drinking behavior. Under some circumstances, this behavioral change is accompanied by changes in plasma and central angiotensin concentrations, and it has been proposed that these changes in angiotensin levels induce the thirst‐related behaviors. In response to dehydration, the spadefoot toad, Scaphiopus couchii, exhibits thirst‐related behavior in the form of cutaneous drinking. This behavior has been termed water absorption response (WR) behavior. Spadefoot toads live in harsh desert environments and are subject annually to dehydrating conditions that may induce thirst‐related behavior. We tested the hypothesis that an increase in WR behavior is associated with both an increase in plasma osmolality and an increase in plasma and brain angiotensin concentrations. First, we determined the degree of dehydration that was necessary to initiate WR behavior. Animals dehydrated to 85% of their standard bladder‐empty weight via deprivation of water exhibited WR behavior more frequently than control toads left in home containers with water available. Next, using the same dehydration methods, we determined the plasma osmolality and sodium concentrations of dehydrated toads. Toads dehydrated to 85% standard weight also had a significant increase in plasma osmolality, but exhibited no overall change in plasma sodium concentrations, indicating that while an overall increase in plasma osmolality appears to be associated with WR behavior in S. couchii, changes in sodium concentrations alone are not sufficient to induce the behavior. Finally, plasma and brain angiotensin concentrations were measured in control toads and toads dehydrated to 85% standard weight. Plasma and brain angiotensin concentrations did not increase in dehydrated toads, indicating that dehydration‐induced WR behavior that is associated with changes in plasma osmolality may not be induced by changes in endogenous angiotensin concentrations in S. couchii. J. Exp. Zool. 286:572–584, 2000. © 2000 Wiley‐Liss, Inc.

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The Role of the Renin-Angiotensin System in the Control of Blood Pressure and Drinking in the European Eel, Anguilla anguilla

Cited by 64 publications

References 0 publications

Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Ambient Temperature Regulates Drinking and Arterial Pressure in Eels

Effects of dehydration on plasma osmolality, thirst-related behavior, and plasma and brain angiotensin concentrations in Couch's spadefoot toad,Scaphiopus couchii

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