The role of the periodontal ligament in bone modeling: The initial development of a time-dependent finite element model

Middleton, J.; Jones, M. L.; Wilson, Adrian N.

doi:10.1016/s0889-5406(96)70176-2

Cited by 153 publications

(77 citation statements)

References 9 publications

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“…Orthodontic tooth movement is ultimately a result of bone adaptation to stresses/strains induced by forces and/or moments in the bone and PDL (Burstone & Pryputniewicz, 1980;Choy et al, 2000;Christiansen & Burstone, 1969;Fukui, 1993;Katona et al, 1995;Kawarizadeh et al, 2003a;Kawarizadeh et al, 2004;Melsen, 1999;Melsen, 2001;Middleton et al, 1996;Nagerl et al, 1991;Smith & Burstone, 1984;Tanne, Burstone & Sakuda, 1989a;Tanne et al, 1989b;Tanne, Sakuda & Burstone, 1987;Toms et al, 2002;van Steenbergen et al, 2005a;van Steenbergen et al, 2005b;Vanden Bulcke et al, 1987;Vanden Bulcke et al, 1986). The changes in the mechanical environment that surrounds the tooth depend not only on the force system, but also on the morphology of the root and alveolar bone (Burstone & Pryputniewicz, 1980;Choy et al, 2000;Nagerl et al, 1991;Tanne et al, 1989a;Tanne et al, 1991).…”

Section: Mechanical Variables In Orthodontic Tooth Movement and Errmentioning

confidence: 99%

“…However, it is still a challenge to accurately quantify 3D experimental variables such as root resorption and bone formation. It is known that the mechanical stimuli for orthodontic responses are the 3D distributed stresses/strains on the root and bone-PDL (periodontal ligament) interface (Andersen et al, 1991a;Andersen, Pedersen & Melsen, 1991b;Cattaneo, Dalstra & Melsen, 2005;Davidovitch, 1991;Fukui, 1993;Jones et al, 2001;Katona et al, 1995;Kawarizadeh et al, 2003a;Kawarizadeh et al, 2004;Krishnan & Davidovitch, 2006;Melsen, 1999;Melsen, 2001;Middleton, Jones & Wilson, 1996;Provatidis, 2002;Roberts, Goodwin & Heiner, 1981;Rygh, 1976;Toms et al, 2002;Wright & Yettram, 1979). Histology provides only 2D data and the results greatly depend on the choice of the representative sections, as well as choice of method of root resorption assessment.…”

Section: Introduction Orthodontic Tooth Movement Bone Response and Rmentioning

confidence: 99%

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Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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Section: Mechanical Variables In Orthodontic Tooth Movement and Errmentioning

confidence: 99%

Section: Introduction Orthodontic Tooth Movement Bone Response and Rmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Mechanical stress evokes biomechanical and structural responses in a variety of cell types in vivo and in vitro (1,2).…”

Section: Introductionmentioning

confidence: 99%

Orthodontic Root Resorption was Associated with the Secretion of IL-6 and IL-8 Stimulated by IL-17in Dental Pulp Cells

et al. 2013

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Orthodontically induced inflammatory root resorption (OIIRR) is a common complication associated with orthodontic tooth movement. The aim of this study was to investigate how dental pulp contributes to root resorption during orthodontic tooth movement. Fifteen male 8-week-old BALB/c mice were subjected to an excessive orthodontic force of 25 g to induce a mesially tipping movement of the upper first molars for nine days. The expression levels of the TRAP, interleukin(IL)-17, IL-17 receptor(IL-17R), IL-6 and keratinocyte chemoattractant (KC; IL-8-related protein in rodents) proteins were determined in dental pulp (DP) by an immunohistochemical analysis. Furthermore, the effects of IL-17 on the production of IL-6 and IL-8 were investigated using human dental pulp (hDP) cells in vitro.Resorption lacunae with multinucleated cells were observed in the 25 g group during the in vivo experimental tooth movement study. Immunoreactivity for IL-17, IL-17R, IL-6 and KC was detected in all of the DP tissues subjected to the orthodontic force on day nine.Moreover, IL-17 increased the release of IL-6 and IL-8 from hDP cells. The results of this study suggest that the IL-17 may aggravate the process of root resorption by increasing the production of IL-6 and IL-8 from hDP cells.

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“…The finite element (FE) method has proven to be a suitable tool for approximating the distribution of stresses in structures in dentistry [1][2][3][4][5][6][7][8][9][10][11][12] . Indeed, since 1980, several three-dimensional FE models of the tooth, including the periodontal ligament (PDL) and alveolar bone, have been created [1][2][3][4][5][6][7][8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, since 1980, several three-dimensional FE models of the tooth, including the periodontal ligament (PDL) and alveolar bone, have been created [1][2][3][4][5][6][7][8][9][10][11][12] . These models have shown, for example, that the predicted stress distribution in the PDL and on the surface of root matched up to the resultant bone remodeling in the alveolar bone.…”

Section: Introductionmentioning

confidence: 99%

Development of Three-dimensional FE Modeling System from the Limited Cone Beam CT Images for Orthodontic Tipping Tooth Movement

et al. 2007

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Previously, numerous three-dimensional finite element (FE) models of the dentoalveolar complex have been developed and stress analyses of orthodontic tooth movements were reported. Most of the models were, however, developed based on average anatomical data, but not on individual data. The aim of this study, therefore, was to investigate dentoalveolar stress distribution by lingual and distal tipping tooth movements using FE models of individual teeth based on the limited cone beam CT (3DX) images. Three extracted teeth (lower canine, upper molar, and lower molar) were used to test the threedimensional reconstruction procedure in terms of accuracy and reproducibility in linear dimensions and sizes. From the stress analysis of the three different models, the equivalent stress in tipping movement concentrated at the cervical region of the PDL and bone crest in all teeth. It was suggested that the FE modeling technique based on 3DX in this study is recommended for the individual determination of optimal orthodontic force for effective tooth movement.

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The role of the periodontal ligament in bone modeling: The initial development of a time-dependent finite element model

Cited by 153 publications

References 9 publications

Orthodontic mechanotransduction and the role of the P2X7 receptor

Orthodontic mechanotransduction and the role of the P2X7 receptor

Orthodontic Root Resorption was Associated with the Secretion of IL-6 and IL-8 Stimulated by IL-17in Dental Pulp Cells

Development of Three-dimensional FE Modeling System from the Limited Cone Beam CT Images for Orthodontic Tipping Tooth Movement

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