The role of the mechanisms of anoikis and autophagy in the pathogenesis of endometriosis (a review)

Adamyan, L. V.; Асатурова, А. В.; Stepanian, A.A.; Popryadukhin, A.Yu.

doi:10.17116/repro201723481-86

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Because autophagy is thought to be a process that contributes not only to the death of damaged cells but also to their preservation (by preventing apoptosis by mitochondrial pathways) [22,23], it can be assumed that in hypertension, regardless of the age of the patients, this mechanism is compensatory active, at least in blood cells.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Structural Characteristics of Platelets and Leukocytes in Patients With Arterial Hypertension Under the Influence of a Hydrogen Sulfide Donor

Kravchuk

Rozova

2020

EUREKA: Health Sciences

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The aim of the research. The influence of hydrogen sulphide donor on some structural characteristics of platelets and leukocytes in patients with arterial hypertension was studied. Materials and methods. The survey involved patients (men) with hypertension aged 30–60 years, who were divided into 2 age groups: 30–40 years and 40–60 years. Control groups (healthy men without signs of hypertension) were randomized by age. Electron microscopic and morphometric research methods were used in the investigation. Results. Electron microscopic and morphometric evaluation of the structure of these cells has shown that it undergoes significant changes depending on patient’s age. In the persons of the older age group, the cells contained a reduced number of dense δ-granules and increased – α-granules, which may indicate an impaired serotonin balance and increased susceptibility to thrombogenesis. The younger age group presented structural changes in platelets in a reversed order. Adding hydrogen sulphide donor at a dose of 400 mg per day (phytopreparation Full Spectrum Garlic – Swanson Health Products, USA) to the traditional therapy of arterial hypertension leads to positive changes in the ultrastructure of the studied cells aimed at restoring the balance of serotonin, reducing the tendency to thrombogenesis, increasing the energy capacity of the mitochondrial apparatus. Conclusion. The obtained results indicate that detected effects significantly depend on the patient’s age (younger people respond more intensively) and the duration of the use of hydrogen sulphide donor (longer use is accompanied by more pronounced positive changes).

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Section: Discussionmentioning

confidence: 99%

Changes in the Structural Characteristics of Platelets and Leukocytes in Patients With Arterial Hypertension Under the Influence of a Hydrogen Sulfide Donor

Kravchuk

Rozova

2020

EUREKA: Health Sciences

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Autophagy as a new link in the mechanism of development of reproductive system disorders (literature review)

Adamyan¹,

Gevorgyan²

2019

Probl. reprod.

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Аутофагия является эволюционным процессом, который направлен на поддержание клеточного гомеостаза путем уменьшения содержания поврежденных органелл и белков, поддержания баланса энергии внутри клетки в стрессовых условиях, которыми являются голодание, гипоксия, гормональная стимуляция, инфекция и другие факторы. При длительном воздействии повреждающих факторов аутофагия, как и апоптоз, может привести клетку к гибели. Представлен обзор роли аутофагии при таких состояниях в репродуктивной системе, как эмбриогенез, имплантация, преждевременная недостаточность яичников, преэклампсия, эндометриоз. Ключевые слова: аутофагия, имплантация эмбриона, преждевременная недостаточность яичников, эндометриоз.

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The role of the mechanisms of anoikis and autophagy in the pathogenesis of endometriosis (a review)

Cited by 2 publications

References 41 publications

Changes in the Structural Characteristics of Platelets and Leukocytes in Patients With Arterial Hypertension Under the Influence of a Hydrogen Sulfide Donor

Changes in the Structural Characteristics of Platelets and Leukocytes in Patients With Arterial Hypertension Under the Influence of a Hydrogen Sulfide Donor

Autophagy as a new link in the mechanism of development of reproductive system disorders (literature review)

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