Changes in the Structural Characteristics of Platelets and Leukocytes in Patients With Arterial Hypertension Under the Influence of a Hydrogen Sulfide Donor

Abstract

The aim of the research. The influence of hydrogen sulphide donor on some structural characteristics of platelets and leukocytes in patients with arterial hypertension was studied. Materials and methods. The survey involved patients (men) with hypertension aged 30–60 years, who were divided into 2 age groups: 30–40 years and 40–60 years. Control groups (healthy men without signs of hypertension) were randomized by age. Electron microscopic and morphometric research methods were used in the investigation. Results. Electron microscopic and morphometric evaluation of the structure of these cells has shown that it undergoes significant changes depending on patient’s age. In the persons of the older age group, the cells contained a reduced number of dense δ-granules and increased – α-granules, which may indicate an impaired serotonin balance and increased susceptibility to thrombogenesis. The younger age group presented structural changes in platelets in a reversed order. Adding hydrogen sulphide donor at a dose of 400 mg per day (phytopreparation Full Spectrum Garlic – Swanson Health Products, USA) to the traditional therapy of arterial hypertension leads to positive changes in the ultrastructure of the studied cells aimed at restoring the balance of serotonin, reducing the tendency to thrombogenesis, increasing the energy capacity of the mitochondrial apparatus. Conclusion. The obtained results indicate that detected effects significantly depend on the patient’s age (younger people respond more intensively) and the duration of the use of hydrogen sulphide donor (longer use is accompanied by more pronounced positive changes).