The Role of the Lymphocyte in the Circulation of the Lymph

The Characteristics of Thoracic Duct Lymph in Man

“…Attempts to locate the thoracic duct post nortem were uniformly unsuccessful unless half cream-half milk had been ingested 3 to 24 hours before cannulation. Satisfactory lymph flow was obtained in 11 patients, 10 637 of whom had leukemia (Table I) were given 15 to 30 minutes before surgical exploration of the duct area. Thoracic duct lymph was obtained for continuous periods of 2 to 13 days in 10 patients (Table II, Figure 3).…”

“…in each 24 hours which calculates to a delivery of approximately 35 x 10' cells per 24 hours into the peripheral circulation (3,9). Since only onethird of this number can be accounted for in the peripheral blood, it has been assumed that the lymphocyte is replaced three times daily and that the intravascular life span of the lymphocyte can be calculated therefrom (8,10,11). Calculations of life span of lymphocytes in the peripheral circulation by this method are based upon the premise of a single securely closed circulation consisting of the flow of lymphocytes from the production site through the thoracic duct into the blood and thence to destruction.…”

On the Relationship between Growing Blood Cells and Blood Vessels

“…The relative distribution of the various blood cell types in each organ may be approximated by following horizontally the density of stippling in the diagram for each organ. tissue (6), and where the lymphatics are well developed, one finds a heavy population of small and medium sized lymphocytes de veloping in the reticulum which surrounds the arterioles and the lymphatics. The vein which emerges from the spleen and drains into the liver is specially marked to signify that the portal venous blood differs from systemic venous blood in that it is under greater pressure, that it contains more oxygen, and that it contains less carbon dioxide (23).…”

The Histochemistry of the Lymphatic Tissue of the Human Tongue and Its Probable Function in Taste

“…There was, in most cases, a sharp line of dem arcation between the absolutely negative cells of the prim ary nodule and the strongly reactive internodular tissue surrounding it (figs. 7,8,10). Occasionally some cells in the.…”

“…6,7,8). The m ajority of the cells of the lym phatic tissue between the prim ary nodules were so strongly reactive th at less than one hour's incubation was enough to show absolutely positive results.…”