The role of the intestinal microflora in experimental colitis

Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis

“…Furthermore, the protective effect of metronidazole in experimental UC has been demonstrated and suggests that anaerobic bacteria play a role in the initial events of experimental colitis in the guinea pig model (Onderdonk et al, 1978).…”

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

“…This fact is supported by the therapeutic benefits of antibiotic and probiotic treatment in IBD patients, 40,41 the observation that specific enteric flora are found more commonly in patients than in controls, 42,43 and studies in a variety of murine strains in which 'spontaneous' colitis seems to be entirely dependent on the presence of a luminal flora. [44][45][46] Autophagy has an important role in physiological and pathological processes, such as degradation of cytoplasmic components, cellular response to nutrient starvation and apoptosis. 47,48 Moreover, autophagy is also relevant in innate 49,50 and adaptive immunity.…”

Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment

“…1) (2). With respect to the pathogenic factors in this colitis model, previous studies have postulated the importance of various factors such as local immunological disturbances (3), the activation of mucosal macrophages (4), effects related to the strong negative-charge of DSS (5), obliteration of the crypt lumina (6) and changes in the intestinal microflora (7). Our previous studies also have postulated the importance of various factors such as the local involvement of reactive oxygen species (8,9), short chain fatty acids (SCFA) (10) and cell cycle arrest (11).…”