Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis

Lucke, Katja; Miehlke, Stephan; Jacobs, Enno; Schuppler, Markus

doi:10.1099/jmm.0.46198-0

Cited by 214 publications

(164 citation statements)

References 49 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…Several studies reported an increase of Bacteroides spp. population level in IBD by the use of both culture-dependent and culture-independent methods (11,16,29,38). However, Conte et al found a decreased population level of anaerobic organisms, especially Bacteroides vulgatus (5).…”

Section: Discussionmentioning

confidence: 99%

Structural Shifts of Mucosa-Associated Lactobacilli and Clostridium leptum Subgroup in Patients with Ulcerative Colitis

Zhang¹,

Liu²,

Zhang³

et al. 2007

J Clin Microbiol

View full text Add to dashboard Cite

To understand the role of mucosa-associated microbiota in the pathogenicity of ulcerative colitis (UC), paired biopsies were obtained during colonoscopy from the ulcerated and nonulcerated gut mucosa of 24 patients with UC. Denaturing gradient gel electrophoresis analysis was employed to profile the composition of the dominant bacteria (16S rRNA gene V3 region) and three important groups: lactobacilli, the Clostridium leptum subgroup, and Bacteroides spp. The Pearson coefficient was used to estimate similarities between the bacterial communities of the paired biopsies for each patient. The average similarity values of bacterial composition between the paired samples were 94.8 ؎ 3.8% for dominant bacteria, 59.9 ؎ 26.1% for lactobacilli, 79.2 ؎ 22.6% for the Clostridium leptum subgroup, and 88.7 ؎ 16.4% for Bacteroides spp. The data revealed that lactobacilli and the Clostridium leptum subgroup were significantly different between the ulcerated and the nonulcerated regions. It also was noted that for lactobacilli, the composition varied significantly between biopsy sites irrespective of the location of UC in the gut but that the composition of the Clostridium leptum subgroup showed significant differences between paired samples from UC in the rectum and not in the left colon. Localized dysbiosis of the mucosa-associated intestinal microflora, especially for lactobacilli and the Clostridium leptum subgroup, may be closely related to UC.

show abstract

Section: Discussionmentioning

confidence: 99%

Structural Shifts of Mucosa-Associated Lactobacilli and Clostridium leptum Subgroup in Patients with Ulcerative Colitis

Zhang¹,

Liu²,

Zhang³

et al. 2007

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Another noteworthy observation is an OTU belonging to Prevotella that is associated with sese controls. Because these bacteria are able to digest mucins and are of increasing clinical relevance for chronic infections, it is possible that they contribute to mucosa impairment (58,59).…”

Section: Discussionmentioning

confidence: 99%

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 ( Secretor ) genotype

Rausch

Rehman

Künzel

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

319

277

View full text Add to dashboard Cite

The FUT2 (Secretor) gene is responsible for the presence of ABO histo-blood group antigens on the gastrointestinal mucosa and in bodily secretions. Individuals lacking a functional copy of FUT2 are known as “nonsecretors” and display an array of differences in susceptibility to infection and disease, including Crohn disease. To determine whether variation in resident microbial communities with respect to FUT2 genotype is a potential factor contributing to susceptibility, we performed 454-based community profiling of the intestinal microbiota in a panel of healthy subjects and Crohn disease patients and determined their genotype for the primary nonsecretor allele in Caucasian populations, W143X (G428A). Consistent with previous studies, we observe significant deviations in the microbial communities of individuals with Crohn disease. Furthermore, the FUT2 genotype explains substantial differences in community composition, diversity, and structure, and we identified several bacterial species displaying disease-by-genotype associations. These findings indicate that alterations in resident microbial communities may in part explain the variety of host susceptibilities surrounding nonsecretor status and that FUT2 is an important genetic factor influencing host–microbial diversity

show abstract

“…[25][26][27] However, most intestinal microbiota cannot be cultured because of anaerobic requirements and complex environments. 12,13 So, molecular approaches which enable the evaluation of alterations in uncultivable bacteria have been employed for analysing microbiota in IBD.…”

Section: Discussionmentioning

confidence: 99%

Faecal microbiota profile of Crohn’s disease determined by terminal restriction fragment length polymorphism analysis

Andoh

Tsujikawa

Sasaki

et al. 2008

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis

Cited by 214 publications

References 49 publications

Structural Shifts of Mucosa-Associated Lactobacilli and Clostridium leptum Subgroup in Patients with Ulcerative Colitis

Structural Shifts of Mucosa-Associated Lactobacilli and Clostridium leptum Subgroup in Patients with Ulcerative Colitis

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 ( Secretor ) genotype

Faecal microbiota profile of Crohn’s disease determined by terminal restriction fragment length polymorphism analysis

Contact Info

Product

Resources

About