The role of the external lateral parabrachial subnucleus in flavor preferences induced by predigested food administered intragastrically

Zafra, María A.; Simon, Maria J.; Molina, Filomena; Puerto, Amadeo

doi:10.1016/s0006-8993(02)03032-9

Cited by 31 publications

(33 citation statements)

References 63 publications

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“…This would appear to converge with our findings and support a positive role for -receptors in the LPBN in motivated behavior. Evidence that the external lateral PBN subserves some aspects of the acquisition of flavor preferences agrees with this view (93).…”

Section: Discussionsupporting

confidence: 56%

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

Wilson

Nicklous

Aloyo

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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. The pontine parabrachial nucleus (PBN) has been implicated in regulating ingestion and contains opioids that promote feeding elsewhere in the brain. We tested the actions of the selective -opioid receptor (-OR) agonist [D-Ala 2 ,N-Me-Phe 4 ,Gly 5 -ol]enkephalin (DAMGO) in the PBN on feeding in male rats with free access to food. Infusing DAMGO (0.5-4.0 nmol/0.5 l) into the lateral parabrachial region (LPBN) increased food intake. The hyperphagic effect was anatomically specific to infusions within the LPBN, dose and time related, and selective for ingestion of chow compared with (nonnutritive) kaolin. The nonselective opioid antagonist naloxone (0.1-10.0 nmol intra-PBN) antagonized DAMGO-induced feeding, with complete blockade by 1.0 nmol and no effect on baseline. The highly selective -opioid antagonist D-Phe-Cys-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP; 1.0 nmol) also prevented this action of DAMGO, but the -antagonist nor-binaltorphimine did not. Naloxone and CTAP (10.0 nmol) decreased intake during scheduled feeding. Thus stimulating -ORs in the LPBN increases feeding, whereas antagonizing these sites inhibits feeding. Together, our results implicate -ORs in the LPBN in the normal regulation of food intake.feeding; hyperphagia; DAMGO; naloxone; CTAP STIMULATING ANY OF THE SUBTYPES of opioid receptors (ORs; , , ␦) or the related orphan receptor for nociceptin increases food intake in mammals (6,24,26,71,77). The orexigenic effects of these treatments are evident particularly in settings using preferred foods for the test diet (e.g., 39, 94, 95), although consumption of standard chow is also enhanced (9, 72). Conversely, drugs that block ORs reduce food intake (11,16,41,49). This hypophagia may occur especially under conditions when opioid pathways are highly activated (53). The data, therefore, suggest that opioid peptides play roles in the physiological control of feeding.The anatomic loci subserving opioidergic feeding are distributed widely throughout the brain. Attention has focused on the nucleus accumbens (NAC) and the rest of the ventral striatum as a critical region (9,72,94,95). Infusing opioid agonists into the ventral tegmental area of the midbrain, which projects onto the ventral striatum, also stimulates feeding (45, 67); this circuitry is consistent with the view assigning a broader role for opioids to support positive affect and appetitive reward (39, 70). Another (probably integrated) circuit is defined by observations that opioid stimulation of the paraventricular hypothalamic nucleus (21, 22) The parabrachial nucleus (PBN) of the pons has bidirectional communication with the PVN, central nucleus of the amygdala, and NTS (19,29,61,62). The multiple subnuclei of the PBN sort afferent input from second-order sensory neurons originating in the NTS and spinal cord (38,83) and distribute the information to rostral targets (19,36,37,68). This sensory processing includes neurotransmission underlying gustatory and visceral function and their convergence (8,30,38).It is logical, then, that the PBN has been imp...

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Section: Discussionsupporting

confidence: 56%

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

Wilson

Nicklous

Aloyo

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

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“…In this experiment, the intragastric administration of nutrients was immediately after intake of the flavored solution. (Zafra et al 2005, submitted), which are perceived by the subjects as rewarding (Puerto et al 1976a;Zafra et al 2002). Furthermore, these results appear to support the suggestion that the LPB lesion in the delayed paradigm not only removes the aversive component of the intragastrically administered natural foods but also converts them into preferred foods, as observed when vanilla (experiment 2a) and water (experiment 2b) intakes were compared on four successive days.…”

Section: Discussionsupporting

confidence: 61%

“…Numerous studies have shown that when this phase is absent, directly administering nutrients into the gastric cavity or gut, major physiological and behavioral dysfunctions are observed (Pavlov 1910;Molina et al 1977;Giduck et al 1987;Kaplan et al 1993;Yamashita et al 1993;Friedman et al 1996;Horn et al 1996;Ramirez et al 1997;Teff 2000). Conversely, when this neuroendocrine process is present in some form, as in studies by our group (Puerto et al 1976a,b;Puerto 1977;Zafra 2000;Zafra et al 2002) and other authors (Liebling et al 1975;Tordoff and Friedman 1986;Ackroff and Sclafani 1994;Ramirez 1994), the intragastric administration of nutrients is reinforcing.…”

Section: Discussionsupporting

confidence: 61%

“…It is our understanding that involvement of the cephalic phase and induction of flavor preferences after the intragastric administration of nutrients can be achieved by utilizing cephalic/pre-digested foods from donor animals (Puerto et al 1976a,b;Puerto 1977;Zafra 2000;Zafra et al 2002) or by the utilization of gustatory stimuli to which saccharin has been added (Liebling et al 1975;Lucas and Sclafani 1989;Ramirez 1994;Sclafani et al 1996;Azzara and Sclafani 1998;Sclafani et al 1999;Sclafani 2002;Ackroff et al 2005). It has been demonstrated that saccharin can induce some responses proper to the cephalic phase of digestion (Berthoud et al 1980;Ionescu et al 1988;Tordoff and Friedman 1989).…”

Section: Discussionmentioning

confidence: 99%

“…Within the parabrachial complex, the lateral parabrachial nucleus (LPB) has been specifically implicated in different intake-related processes, including food intake (Trifunovic and Reilly 2001;Zafra et al 2002;Wilson et al 2003), water intake (Edwards and Johnson 1991;Menani et al 1996;De Gobbi et al 2001;Tanaka et al 2004), and taste aversions induced by toxic or noxious substances (Agü ero et al 1993a,b;Cubero and Puerto 2000;Chambers and Wang 2004).…”

Section: Introductionmentioning

confidence: 99%

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Lesions of the lateral parabrachial area block the aversive component and induced-flavor preference for the delayed intragastric administration of nutrients in rats: Effects on subsequent food and water intake

Zafra¹,

Simon²,

Molina³

et al. 2005

Nutritional Neuroscience

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The aim of this study was to examine the function of the lateral parabrachial area (LPB) in relation to the intragastric administration of nutrients. The consumption of flavors associated with intragastric nutrient administration and the subsequent food and water intake were measured in rats with lesions in the LPB. The results showed that bilateral LPB lesions prevented development of aversions and induced flavor preference when there was a delay between the presentation of a flavor and the intragastric administration of nutrients. However, these lesions did not disrupt development of the aversive process when there was no delay between the presentations. Likewise, the LPB lesions increased subsequent food intake when there was a delay but not when there was no delay between the presentations. In contrast, the water intake was reduced in both situations. These results are interpreted in terms of a dual visceral system for processing the intragastric effects of foods.

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Cocaine- and amphetamine-regulated transcript peptide immunoreactivity in the brain of the CCK-1 receptor deficient obese OLETF rat

2009

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Cocaine- and amphetamine regulated transcript (CART) peptide is expressed in brain areas involved in homeostatic regulation and reward. CART has been shown to reduce food intake but the underlying mechanisms and the relevance of this effect to obesity yet remain unknown. Therefore, we used immunohistochemistry to investigate expression of CART peptide in various brain regions of the obese Otsuka Long Evans Tokushima Fatty (OLETF) rats lacking the CCK-1 receptor. Analysis revealed that whereas the distribution of CART peptide-immunoreactive neurons and axonal networks was identical in OLETF rats and lean controls, intensity of CART immunoreactivity was significantly reduced in the rostral part of the nucleus accumbens (p<0.01), the basolateral complex of the amygdala (p<0.05), and the rostro-medial nucleus of solitary tract (p<0.001) of the OLETF rats. These areas are involved in reward and integration of taste and viscerosensory information and have been previously associated with altered functions in this strain. The findings suggest that in addition to previously described deficits in peripheral satiety signals and augmented orexigenic regulation, the anorectic effect of CART peptide may also be diminished in OLETF rats.

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The role of the external lateral parabrachial subnucleus in flavor preferences induced by predigested food administered intragastrically

Cited by 31 publications

References 63 publications

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

Lesions of the lateral parabrachial area block the aversive component and induced-flavor preference for the delayed intragastric administration of nutrients in rats: Effects on subsequent food and water intake

Cocaine- and amphetamine-regulated transcript peptide immunoreactivity in the brain of the CCK-1 receptor deficient obese OLETF rat

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