The Role of the Dura in Cranial Bone Regeneration in the Immature Animal

Hobar, P. Craig; Schreiber, Jonathan; McCarthy, Joseph G.; Thomas, P. A.

doi:10.1097/00006534-199309000-00003

Cited by 113 publications

(68 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In children younger than 1 year [1] and in immature animals [2], subtotal calvariectomy with dural preservation is associated with complete calvarial reossification. Dural capacity to induce calvarial regeneration is slowly lost with age [1, 3, 4].…”

Section: Introductionmentioning

confidence: 99%

Early Dural Reaction to Polylactide in Cranial Defects in Rabbits

et al. 2005

View full text Add to dashboard Cite

Restoring the bone integrity to injured calvariae remains a challenge to surgeons. In this study, the dural biocompatibility of biodegradable poly-L/DL-lactide 80/20 and 70/30 defect covers, designed for guided bone regeneration, was assessed. In each of the 16 test rabbits, bilateral (8.3 mm) cranial defects were created. The different covers were applied to one defect each in every rabbit and consisted of three parts: an epicranial cover, a spacer, and a dural cover. All defects had closed after 8 weeks due to new bone formation. A few giant cells were found at the cover-to-dura interface in equal numbers for both covers. Dural bone formation was present in 15 of 16 rabbits and progressed unhindered by the defect cover or its early degradation products.

show abstract

Section: Introductionmentioning

confidence: 99%

Early Dural Reaction to Polylactide in Cranial Defects in Rabbits

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Hobar et al 15 emphasize the importance of the dura mater in the regeneration of critical defects in pigs and raise a correlation of this role to the age of the animal. Similarly, the injury is believed to interfere in the stimulus for bone formation when studying the role of stem cells in bone repair, for example.…”

Section: Discussionmentioning

confidence: 99%

“…The 16-week time point was used for being previously demonstrated as sufficient length of time to allow measurable bony repair in other models of adult calvarial defect healing 15,16 .…”

Section: Discussionmentioning

confidence: 99%

An experimental model for the study of craniofacial deformities

Costa¹,

Kobayashi²,

Bueno³

et al. 2010

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose:To develop an experimental surgical model in rats for the study of craniofacial abnormalities. Methods: Full thickness calvarial defects with 10x10-mm and 5x8-mm dimensions were created in 40 male NIS Wistar rats, body weight ranging from 320 to 420 g. The animals were equally divided into two groups. The periosteum was removed and dura mater was left intact. Animals were killed at 8 and 16 weeks postoperatively and cranial tissue samples were taken from the defects for histological analysis. Results: Cranial defects remained open even after 16 weeks postoperatively. Conclusion: The experimental model with 5x8-mm defects in the parietal region with the removal of the periosteum and maintenance of the integrity of the dura mater are critical and might be used for the study of cranial bone defects in craniofacial abnormalities. Key words: Bone Regeneration. Craniofacial Abnormalities. Parietal Bone. Rats. RESUMOObjetivo: Desenvolver um modelo experimental em ratos para o estudo de deformidades craniofaciais. Métodos: Foram realizados defeitos ósseos de espessura total com diâmetro de 5 x 8 mm e 10 x 10mm na calota craniana em 40 ratos, machos, NIS Wistar, com peso de 320 a 420 g divididos igualmente em dois grupos. O periósteo foi retirado e a dura-máter mantida intacta. Os animais foram sacrificados na 8ª e 16ª semana de pós-operatório e amostras de tecido ósseo foram extraídas para realização da análise histológica. Resultados: Os defeitos cranianos permaneceram abertos mesmo após 16 semanas após a cirurgia. Conclusão: O modelo experimental com defeitos de 5x8mm na região parietal, com remoção do periósteo e manutenção da integridade da dura-máter são considerados críticos, e poderá ser utilizado para o estudo dos defeitos ósseos cranianos nas anomalias craniofaciais.

show abstract

“…17 Further support of the observation that the dura mater is influential in bony healing is the finding that critical-size bony defects in adult guinea pigs can be rescued by allotransplantation of juvenile guinea pig dura mater to the adult defect. 41 To preserve the dura mater, craniotomies in mice should to be performed with the aid of a dissecting microscope. The other option, of course, is to use a largeranimal model such as the rat.…”

Section: Small-animal Modelsmentioning

confidence: 99%

Cranial bone defects: current and future strategies

Szpalski¹,

Barr²,

Wetterau³

et al. 2010

FOC

177

118

View full text Add to dashboard Cite

Bony defects in the craniomaxillofacial skeleton remain a major and challenging health concern. Surgeons have been trying for centuries to restore functionality and aesthetic appearance using autografts, allografts, and even xenografts without entirely satisfactory results. As a result, physicians, scientists, and engineers have been trying for the past few decades to develop new techniques to improve bone growth and bone healing. In this review, the authors summarize the advantages and limitations of current animal models; describe current materials used as scaffolds, cell-based, and protein-based therapies; and lastly highlight areas for future investigation. The purpose of this review is to highlight the major scaffold-, cell-, and protein-based preclinical tools that are currently being developed to repair cranial defects.

show abstract

The Role of the Dura in Cranial Bone Regeneration in the Immature Animal

Cited by 113 publications

References 0 publications

Early Dural Reaction to Polylactide in Cranial Defects in Rabbits

Early Dural Reaction to Polylactide in Cranial Defects in Rabbits

An experimental model for the study of craniofacial deformities

Cranial bone defects: current and future strategies

Contact Info

Product

Resources

About