The role of the cortical parts of the cerebellar hemispheres in discrimination learning of cats

Davis, Hallowell; Watkins, G. M.; Angermeier, W. F.; Rubia, Francisco J.

doi:10.1007/bf00586974

Cited by 8 publications

(8 citation statements)

References 5 publications

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“…Although both experimental and control subjects showed good acquisition of an initial maze task, lesioned animals were demonstrably impaired when re-quir~ to shift response strategies to perform a subsequent alternation task. Furthermore, perseveration of response strategy is consistent with reports that animals with cerebellar lesions demonstrate impaired extinction of a visual discrimination task (Rubia, Angermeier, Davis, & Watkins, 1969;Davis et al, 1970).…”

Section: Discussionsupporting

confidence: 88%

“…Mazes that require sequential alternations of left and right turns present tremendous difficulties for rats with paleocerebellar lesions (Pellegrino & Altman, 1979), and more extensive injuries have been shown to impair performance in less complex mazes that do not require such alternations (Lashley & McCarthy, 1926;Thompson, 1974). Similar deficits have been demonstrated with two-choice visual discrimination tasks (Buchtel, 1970;Davis, Watkins, Angermeier, & Rubia, 1970). These deficits appear to result from the animal's inability to inhibit responding or to switch response strategies.…”

Section: William Timothy Kirkmentioning

confidence: 84%

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The effect of previous experience upon operant performance following cerebellar lesions in the rat

Kirk

1985

Psychobiology

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Lesions of the fastigial nuclei and cerebellar vermis, but not lesions of the dentate nuclei, were found to produce marked performance deficits on a differential reinforcement of low rates (DRL) schedule of reinforcement. This deficit was characterized by an abnormal number and distribution of responses within the schedule interval. Lesions, however, did not produce a deficit following preoperative training or when subjects were tested on a fixed-interval (FI) schedule. In addition, when DRL and FI performance was contrasted, all subjects were responsive to schedule contingencies. Results suggest that the DRL deficit following cerebellar lesions is due to a tendency to perseverate in response strategies, and is not related to a global disruption of timing or a pervasive inability to suppress responding.

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Section: Discussionsupporting

confidence: 88%

Section: William Timothy Kirkmentioning

confidence: 84%

The effect of previous experience upon operant performance following cerebellar lesions in the rat

Kirk

1985

Psychobiology

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“…Thus, it appears probable that in the current study reductions in the number of Purkinje cells in chimeric mice leads to a disruption in dopamine transmission in the MPFC, and this in turn leads to increased and repetitive lever‐pressing that could be interpreted as a deficit in inhibitory response control. Interestingly, an early study on cats with bilateral cerebellar cortical ablation demonstrated an impaired ability to inhibit bar‐pressing during periods of non‐reward in an operant task, a structure–function relationship perhaps similar to our findings in cerebellar deficient chimeric mice (Davis et al. , 1970).…”

Section: Discussionsupporting

confidence: 86%

Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism

Martin

Goldowitz

Mittleman

2010

Eur J of Neuroscience

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Repetitive behaviors and hyperactivity are common features of developmental disorders, including autism. Neuropathology of the cerebellum is also a frequent occurrence in autism and other developmental disorders. Recent studies have indicated that cerebellar pathology may play a causal role in the generation of repetitive and hyperactive behaviors. In this study, we examined the relationship between cerebellar pathology and these behaviors in a mouse model of Purkinje cell loss. Specifically, we made aggregation chimeras between Lc/+ mutant embryos and +/+ embryos. Lc/+ mice lose 100% of their Purkinje cells postnatally due to a cell-intrinsic gain-of-function mutation. Through our histological examination, we demonstrated that Lc/+↔+/+ chimeric mice have Purkinje cells ranging from zero to normal numbers. Our analysis of these chimeric cerebella confirmed previous studies on Purkinje cell lineage. The results of both open-field activity and hole-board exploration testing indicated negative relationships between Purkinje cell number and measures of activity and investigatory nose-poking. Additionally, in a progressive-ratio operant paradigm, we found that Lc/+ mice lever-pressed significantly less than +/+ controls, which led to significantly lower breakpoints in this group. In contrast, chimeric mice lever-pressed significantly more than controls and this repetitive lever-pressing behavior was significantly and negatively correlated with total Purkinje cell numbers. Although the performance of Lc/+ mice is probably related to their motor deficits, the significant relationships between Purkinje cell number and repetitive lever-pressing behavior as well as open-field activity measures provide support for a role of cerebellar pathology in generating repetitive behavior and increased activity in chimeric mice.

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“…In addition, rats with large cerebellar lesions have been shown to exhibit perseverative deficits in maze tasks that do not require sequential alternations (Lashley & McCarthy, 1926;Thompson, 1974). A similar pattern of results has been obtained with the cat in a task requiring inhibition of responding (Davis, Watkins, Angermeier, & Rubia, 1970).…”

supporting

confidence: 54%

Effects of paleocerebellar lesions on DRL performance in the albino rat.

Kirk¹,

Berntson²,

Hothersall³

1982

Journal of Comparative and Physiological Psychology

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The role of the cortical parts of the cerebellar hemispheres in discrimination learning of cats

Cited by 8 publications

References 5 publications

The effect of previous experience upon operant performance following cerebellar lesions in the rat

The effect of previous experience upon operant performance following cerebellar lesions in the rat

Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism

Effects of paleocerebellar lesions on DRL performance in the albino rat.

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