Effects of paleocerebellar lesions on DRL performance in the albino rat.

Kirk, William T.; Berntson, Gary G.; Hothersall, David

doi:10.1037/h0077893

Cited by 20 publications

(12 citation statements)

References 42 publications

(52 reference statements)

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“…However, this result could also be interpreted as the presence of perseverative tendencies disrupting performances requiring response alternation. In fact, perseverative tendencies are also reported in tasks of operant conditioning or of spatial discrimination following cerebellar lesions other than HCb (Kirk et al, 1982;Berridge and Whishaw, 1992). Moreover, since clinical reports (Akshoomoff and Courchesne, 1992) show an involvement of cerebellar networks in facilitation of rapid and accurate shifts of selective attention, the possibility that our spatial reversal learning result is due to attentive rigidity must be taken into account.…”

Section: Discussionmentioning

confidence: 84%

Cerebellar Contribution to Spatial Event Processing: Right/Left Discrimination Abilities in Rats

Molinari

Grammaldo

Petrosini

1997

Eur J of Neuroscience

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Recently, we demonstrated the involvement of cerebellar circuits in the procedural components of spatial information processing by testing hemicerebellectomized (HCbed) rats in classical spatial paradigms, such as the Morris Water Maze and the water T-maze. Since procedural components are strongly present in these tests, an impairment also in processing more abstract spatial information, linked to 'where an object is' rather than to 'how to find it', could be hidden by the severe procedural deficits. On this basis, we investigated the influence of cerebellar lesions on spatial abilities strictly reducing procedural variables by employing an active avoidance task, first without and then with a request for right/left discrimination. In the two-way active avoidance task without spatial requests, controls and cerebellar operated rats developed active avoidance responses which were not statistically different, demonstrating that this kind of associative learning is not significantly affected by hemicerebellectomy (HCb). A second experimental group of cerebellar lesioned rats was tested in a modified version of this basic paradigm in which a right/left discrimination request was added. This group displayed severe deficits, which even in the last testing sessions prevented them from performing comparably to the control animals. Reversal of the rewarded choice, even if it affected the performances of both controls and operated rats in the first inversion trials, elicited the lowest number of correct responses in HCbed rats throughout the entire spatial reversal learning, suggesting a severe deficit in the ability to change an initially learned behaviour. These results demonstrate that, beside having a marked impairment in facing procedural components of spatial processing, cerebellar lesioned rats are severely defective also in right/left discrimination tasks, suggesting a role of cerebellar networks also in the discriminative spatial information processing.

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Section: Discussionmentioning

confidence: 84%

Cerebellar Contribution to Spatial Event Processing: Right/Left Discrimination Abilities in Rats

Molinari

Grammaldo

Petrosini

1997

Eur J of Neuroscience

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“…Such behavioral sequelae are reminiscent of motor deficits seen following cerebellar injury; dysmetria, dysdiadochokinesis, and the decomposition of movement. Moreover, previous investigation in this laboratory (Kirk, Berntson, & Hothersall;1982) has demonstrated that subjects with paleocerebellar lesions exhibit a pronounced performance deficit when required to specifically withhold a previously established operant response in a differential reinforcement of low rates (DRL) schedule. This deficit, however, was overcome when an overt "collateral" behavior was made available.…”

Section: William Timothy Kirkmentioning

confidence: 99%

The effect of previous experience upon operant performance following cerebellar lesions in the rat

Kirk

1985

Psychobiology

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Lesions of the fastigial nuclei and cerebellar vermis, but not lesions of the dentate nuclei, were found to produce marked performance deficits on a differential reinforcement of low rates (DRL) schedule of reinforcement. This deficit was characterized by an abnormal number and distribution of responses within the schedule interval. Lesions, however, did not produce a deficit following preoperative training or when subjects were tested on a fixed-interval (FI) schedule. In addition, when DRL and FI performance was contrasted, all subjects were responsive to schedule contingencies. Results suggest that the DRL deficit following cerebellar lesions is due to a tendency to perseverate in response strategies, and is not related to a global disruption of timing or a pervasive inability to suppress responding.

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“…A behavioral parallel to these latter deficits involving the disintegration between patterns of behavior is suggested by results on DRL performance in rats with cerebellar lesions (Kirk, Berntson, & Hothersall, 1982). DRL (differential reinforcement of low rates of responding) performance requires the animal to 'emit a response and then to withhold that response for a specified period of time.…”

Section: The Modulatory Role Of the Cerebellum And The Consequences Omentioning

confidence: 99%

The paleocerebellum and the integration of behavioral function

1982

Self Cite

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The role of the cerebellum in motor function is well documented. Additional data clearly im· plicate the cerebellum in the regulation of sensory processes and autonomic functions, and more recent findings establish an influence of cerebellar systems on the regulation of emotional and motivational behaviors. The cerebellum provides extensive projections to brain· stem and limbic mechanisms that have been implicated in behavioral regulation, and experimen· tal manipulations of the cerebellum have been found to profoundly affect behavioral processes. In the present paper, w~ review some of these findings and offer a conceptual view of cerebellar function that reconciles these apparently disparate actions. We suggest that the cerebellum exerts functionally similar influences at all levels of sensorimotor and behavioral orga· nization. This model provides a conceptual framework for understanding the behavioral consequences of cerebellar dysfunctions, which we suggest can be viewed as behavioral parallels to the classical cerebellar motor syndromes. Data implicating cerebellar systems in the pathogenesis of developmental disturbances in behavioral processes are also considered in the con· text of the present conception of cerebellar·behavioral function.

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Effects of paleocerebellar lesions on DRL performance in the albino rat.

Cited by 20 publications

References 42 publications

Cerebellar Contribution to Spatial Event Processing: Right/Left Discrimination Abilities in Rats

Cerebellar Contribution to Spatial Event Processing: Right/Left Discrimination Abilities in Rats

The effect of previous experience upon operant performance following cerebellar lesions in the rat

The paleocerebellum and the integration of behavioral function

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