The role of the cerebellum in explicit and incidental processing of facial emotional expressions: A study with transcranial magnetic stimulation

Ferrari, Chiara; Oldrati, Viola; Gallucci, Marcello; Vecchi, Tomaso; Cattaneo, Zaira

doi:10.1016/j.neuroimage.2017.12.026

Cited by 63 publications

(52 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering the specific cerebellar areas, visual imagery probably involved lobule VI and Crus-I in MVN as well as in LVN, providing the basis for spatial transformations and mental rotation of objects as well as movement perception and planning ( Cattaneo et al, 2014 ; Ferrari et al, 2018 ). Language processing in LN was associated to FC change in lobule VI, Crus-I and Crus-II.…”

Section: Discussionmentioning

confidence: 99%

Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing

Castellazzi

Bruno²,

Toosy

et al. 2018

Front. Cell. Neurosci.

View full text Add to dashboard Cite

While task-dependent responses of specific brain areas during cognitive tasks are well established, much less is known about the changes occurring in resting state networks (RSNs) in relation to continuous cognitive processing. In particular, the functional involvement of cerebro-cerebellar loops connecting the posterior cerebellum to associative cortices, remains unclear. In this study, 22 healthy volunteers underwent a multi-session functional magnetic resonance imaging (fMRI) protocol composed of four consecutive 8-min resting state fMRI (rs-fMRI) scans. After a first control scan, participants listened to a narrated story for the entire duration of the second rs-fMRI scan; two further rs-fMRI scans followed the end of story listening. The story plot was purposely designed to stimulate specific cognitive processes that are known to involve the cerebro-cerebellar loops. Almost all of the identified 15 RSNs showed changes in functional connectivity (FC) during and for several minutes after the story. The FC changes mainly occurred in the frontal and prefrontal cortices and in the posterior cerebellum, especially in Crus I-II and lobule VI. The FC changes occurred in cerebellar clusters belonging to different RSNs, including the cerebellar network (CBLN), sensory networks (lateral visual network, LVN; medial visual network, MVN) and cognitive networks (default mode network, DMN; executive control network, ECN; right and left ventral attention networks, RVAN and LVAN; salience network, SN; language network, LN; and working memory network, WMN). Interestingly, a k-means analysis of FC changes revealed clustering of FCN, ECN, and WMN, which are all involved in working memory functions, CBLN, DMN, and SN, which play a key-role in attention switching, and RSNs involved in visual imagery. These results show that the cerebellum is deeply entrained in well-structured network clusters, which reflect multiple aspects of cognitive processing, during and beyond the conclusion of auditory stimulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing

Castellazzi

Bruno²,

Toosy

et al. 2018

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Moreover, our findings underlined functional differences depending on the anterior/medial-to-posterior/lateral gradient in lobule VI, in that the more anterior medial lobule VI appears to modulate early movement identification, while the more posterior lateral Crus I is likely to modulate later higher-level cortical processing. Accordingly, we have recently demonstrated [ 174 , 175 ] that TMS over the left posterior cerebellar hemisphere also affects discrimination of emotional facial and body expressions (shown in static pictures of real-life individuals), converging in pointing to the causal role of this posterolateral region in inferring others’ mental states from observation of their body language.…”

Section: The Cerebellum and Body Readingmentioning

confidence: 99%

Consensus Paper: Cerebellum and Social Cognition

et al. 2020

Self Cite

View full text Add to dashboard Cite

The traditional view on the cerebellum is that it controls motor behavior. Although recent work has revealed that the cerebellum supports also nonmotor functions such as cognition and affect, only during the last 5 years it has become evident that the cerebellum also plays an important social role. This role is evident in social cognition based on interpreting goal-directed actions through the movements of individuals (social “mirroring”) which is very close to its original role in motor learning, as well as in social understanding of other individuals’ mental state, such as their intentions, beliefs, past behaviors, future aspirations, and personality traits (social “mentalizing”). Most of this mentalizing role is supported by the posterior cerebellum (e.g., Crus I and II). The most dominant hypothesis is that the cerebellum assists in learning and understanding social action sequences, and so facilitates social cognition by supporting optimal predictions about imminent or future social interaction and cooperation. This consensus paper brings together experts from different fields to discuss recent efforts in understanding the role of the cerebellum in social cognition, and the understanding of social behaviors and mental states by others, its effect on clinical impairments such as cerebellar ataxia and autism spectrum disorder, and how the cerebellum can become a potential target for noninvasive brain stimulation as a therapeutic intervention. We report on the most recent empirical findings and techniques for understanding and manipulating cerebellar circuits in humans. Cerebellar circuitry appears now as a key structure to elucidate social interactions.

show abstract

“…Traditionally, the function of the cerebellum is considered to be movement coordination (30). However, with the development and application of neuroimaging technology in recent years, the understanding on the role of cerebellum, particularly the cerebellar inferior lobe, has expanded to include emotional processing (31).…”

Section: Discussionmentioning

confidence: 99%

Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study

Shi

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

The aim of the present study was to investigate the altered spontaneous brain activity in patients with corneal ulcer (CU) through the amplitude of low-frequency fluctuation (ALFF) technique and the association with their visual performance. A total of 40 patients with CU and 40 healthy controls (HCs) matched for sex, age and educational level were enrolled. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed to examine the probands. Spontaneous cerebral activity variations were investigated using the ALFF technique. The average ALFF values of the CU patients and the HCs were classified by utilizing receiver operating characteristic (ROC) curves. Contrary to HCs, the CU patients had significantly lower ALFF values in the left cerebellar anterior lobe, right middle frontal gyrus and left middle frontal gyrus, but higher ALFF values in the right cerebellar inferior lobe, left cerebellar inferior lobe, left inferior temporal gyrus, right fusiform gyrus, left superior frontal gyrus, right angular gyrus and bilateral superior frontal gyrus. ROC curve analysis of each brain region indicated that the accuracy of ALFF value specificity between the CU and HCs of the area under the curve was perfect. In conclusion, abnormal spontaneous activities were detected in numerous brain regions of CU patients, which may provide useful information for understanding the dysfunction of CU. These activity changes in brain regions may be used as effective clinical indicators for CU.

show abstract

The role of the cerebellum in explicit and incidental processing of facial emotional expressions: A study with transcranial magnetic stimulation

Cited by 63 publications

References 101 publications

Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing

Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing

Consensus Paper: Cerebellum and Social Cognition

Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study

Contact Info

Product

Resources

About