Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study

Abstract

The aim of the present study was to investigate the altered spontaneous brain activity in patients with corneal ulcer (CU) through the amplitude of low-frequency fluctuation (ALFF) technique and the association with their visual performance. A total of 40 patients with CU and 40 healthy controls (HCs) matched for sex, age and educational level were enrolled. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed to examine the probands. Spontaneous cerebral activity variations were investigated using the ALFF technique. The average ALFF values of the CU patients and the HCs were classified by utilizing receiver operating characteristic (ROC) curves. Contrary to HCs, the CU patients had significantly lower ALFF values in the left cerebellar anterior lobe, right middle frontal gyrus and left middle frontal gyrus, but higher ALFF values in the right cerebellar inferior lobe, left cerebellar inferior lobe, left inferior temporal gyrus, right fusiform gyrus, left superior frontal gyrus, right angular gyrus and bilateral superior frontal gyrus. ROC curve analysis of each brain region indicated that the accuracy of ALFF value specificity between the CU and HCs of the area under the curve was perfect. In conclusion, abnormal spontaneous activities were detected in numerous brain regions of CU patients, which may provide useful information for understanding the dysfunction of CU. These activity changes in brain regions may be used as effective clinical indicators for CU.

Altered spontaneous brain activity patterns in diabetic patients with vitreous hemorrhage using amplitude of low‑frequency fluctuation: A resting‑state fMRI study

“…in the present study, a notable decline in alFF values in the right iFG of type-2 diabetic patients with VH was observed, suggesting that VH may cause impairment of language function in this setting. The SFG is the marginal gyrus, accounting for approximately one-third of the human frontal lobe (39). using fMri experiments, Goldberg et al (40) demonstrated that the SFG was related to self-consciousness and coordinated with the movement of the sensory system.…”

“…The SFG is the marginal gyrus, accounting for approximately one-third of the human frontal lobe ( 39 ). Using fMRI experiments, Goldberg et al ( 40 ) demonstrated that the SFG was related to self-consciousness and coordinated with the movement of the sensory system.…”

Altered spontaneous brain activity patterns in patients with neovascular glaucoma using amplitude of low‐frequency fluctuations: A functional magnetic resonance imaging study

“…Ogiso et al (2000) indicated that the precuneus also participates in motion image perception, and transmits motion signals to the supplementary motion area. Shi et al (2019) showed that the ALFF values of the right precuneus were decreased in PAAG patients;…”

“…The data were preprocessed with the Data Processing Assistant for resting‐state fMRI (rs‐fMRI; DPARSFA 4.0; http://rfmri.org/DPARSF), which was based on the rs‐fMRI Data Analysis Toolkit (REST; http://www.restfmri.net) and statistical parametric mapping (SPM; http://www.fil.ion.ucl.ac.uk/spm). This processing method has been described in detail previously (Shi et al., 2019).…”

“…ALFF is a reliable biomarker for many nervous system diseases, including Parkinson's disease , epilepsy (Wang et al, 2015), and schizophrenia (Zhang et al, 2018). In addition, there are many fMRI studies that have used ALFF to analyze the changes in spontaneous brain activity patterns in some ophthalmic illnesses, such as strabismus, optic neuritis, monocular blindness, retinal detachment, and retinal vein occlusion (Huang, Cai, et al, 2015;Li et al, 2016;Min et al, 2018;Shi et al, 2019;Wu et al, 2019) (Table 1).…”