The role of the cell surface in the mechanism of the action of antineoplastic drugs (literature survey)

Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)

“…Several different strategies are currently being studied to target HSPGs including their inhibition by dispirotripiperazine-based compounds [ 13 ]. According to in vitro studies, a representative of the class of dispirotripiperazines, DSTP-27, binds to heparan sulfate proteoglycans [ 57 ]. It may be assumed that this binding occurs through electrostatic interactions between the negatively charged heparin/heparan and the positively charged dispirotripiperazine fragment of the molecules and also through hydrogen-bonding of nitro-pyrimidines with functional groups of HSPG.…”

“…Pol'shakov et al found that the guanine residues may be the main binding sites for prospidine to DNA, in contrast to spirobromine, which does not bind to them [ 55 ]. Moreover, Geodakyan and Chernov suggested that the effect of prospidine on intracellular processes in tumor cells may be mediated by the effect of the drug on the permeability of their plasma membrane [ 56 , 57 ]. But these studies were carried out many years ago and have not yet been confirmed with modern methods.…”