Transforming Growth Factor-Β in Cancer Therapy, Volume I 2008
DOI: 10.1007/978-1-59745-292-2_36
|View full text |Cite
|
Sign up to set email alerts
|

The Role of TGF-β in Bleomycin Induced Pulmonary Fibrosis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
3
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
2
1

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(5 citation statements)
references
References 78 publications
0
3
0
Order By: Relevance
“…This accumulation is associated with increases in the levels of systemic and microenvironmental pro-inflammatory cytokines (TGF-β, CXCL1 and others), which precede the appearance of the pro-fibrotic markers (fibronectin and pro-collagen 1) and of fibrosis 5 . Abnormal expression of P-SEL by endothelial cells 10 and of TGF-β by numerous cell types, including endothelial cells, epithelial cells, alveolar type II cells and macrophages 53,54 , has been implicated in the development of fibrosis in the lungs of bleomycin-treated animals. High levels of TGF-β produced by the alveolar Type II cells were also associated with the development of fibrosis in the Tamoxifen-treated SP-CI73T mouse model 25 .…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…This accumulation is associated with increases in the levels of systemic and microenvironmental pro-inflammatory cytokines (TGF-β, CXCL1 and others), which precede the appearance of the pro-fibrotic markers (fibronectin and pro-collagen 1) and of fibrosis 5 . Abnormal expression of P-SEL by endothelial cells 10 and of TGF-β by numerous cell types, including endothelial cells, epithelial cells, alveolar type II cells and macrophages 53,54 , has been implicated in the development of fibrosis in the lungs of bleomycin-treated animals. High levels of TGF-β produced by the alveolar Type II cells were also associated with the development of fibrosis in the Tamoxifen-treated SP-CI73T mouse model 25 .…”
Section: Discussionmentioning
confidence: 99%
“…This accumulation is associated with an increase in the levels of systemic and microenvironmental pro-inflammatory cytokines (TGF-β, CXCL1 and others), which precede pro-fibrotic markers (fibronectin and procollagen 1), eventually leading to fibrosis 5 . Abnormal expression of P-SEL by endothelial cells 10 and of TGF-β by numerous cell types, including endothelial cells, epithelial cells, type II pneumocytes and alveolar macrophages 50,51 , has been implicated in the development of fibrosis in the lungs of bleomycin-treated animals. In addition, although CXCL1 is elevated in broncoalveolar lavages of these mice 58 , the cells responsible for its production are not yet been identified.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…BLM exerts anti-tumorigenic effects by inducing DNA strand destruction in cancer cells [ 17 , 18 ]; however, it has deadly side effects, causing fibrosis in patients [ 19 , 20 ]. BLM has been shown to increase ROS production in pulmonary alveolar tissues and induce inflammatory cell activation, such as macrophage activation and infiltration in connective tissues [ 21 ]. Moreover, BLM-induced ROS is implicated in the conversion of TGF-β from a latent to an active form in alveolar epithelial cells [ 22 ].…”
Section: Discussionmentioning
confidence: 99%