Spatio-temporal representations in frame sequences play an important role in the task of action recognition. Previously, a method of using optical flow as a temporal information in combination with a set of RGB images that contain spatial information has shown great performance enhancement in the action recognition tasks. However, it has an expensive computational cost and requires two-stream (RGB and optical flow) framework. In this paper, we propose MFNet (Motion Feature Network) containing motion blocks which make it possible to encode spatiotemporal information between adjacent frames in a unified network that can be trained end-to-end. The motion block can be attached to any existing CNN-based action recognition frameworks with only a small additional cost. We evaluated our network on two of the action recognition datasets (Jester and Something-Something) and achieved competitive performances for both datasets by training the networks from scratch.
Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells and cytokines. Echinochrome A (EchA), a natural pigment isolated from sea urchins, has been demonstrated to have antioxidant activities and beneficial effects in various disease models. The present study demonstrates for the first time that EchA treatment alleviates bleomycin-induced scleroderma by normalizing dermal thickness and suppressing collagen deposition in vivo. EchA treatment reduces the number of activated myofibroblasts expressing α-SMA, vimentin, and phosphorylated Smad3 in bleomycin-induced scleroderma. In addition, it decreased the number of macrophages, including M1 and M2 types in the affected skin, suggesting the induction of an anti-inflammatory effect. Furthermore, EchA treatment markedly attenuated serum levels of inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ, in a murine scleroderma model. Taken together, these results suggest that EchA is highly useful for the treatment of scleroderma, exerting anti-fibrosis and anti-inflammatory effects.
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