The role of Tenascin‐C and Twist1 in gastric cancer: cancer progression and prognosis

Abstract

The aim of the present study was to identify the relation between Tenascin‐C (TNC) and Twist1 and determine their clinical significance in gastric cancer (GC). We analyzed the expression of TNC and Twist1 in 159 GC samples and in 91 non‐tumor samples using immunohistochemistry. In this study, TNC expression in stromal fibroblasts of GC was remarkably higher than non‐tumor gastric lesions. The expression of TNC in GC stromal fibroblasts was significantly associated with pT stage, lymph node metastasis, distant metastasis. Twist1 expression in stromal fibroblasts of GC was remarkably higher than non‐tumor gastric lesions. Twist1 expression in the stromal fibroblasts of GC was associated with tumor size, lymph node metastasis, and clinical stage. Furthermore, TNC expression levels in GC stromal fibroblasts were positively associated with Twist1. The simultaneous expression of TNC and Twist1 was significantly higher in stromal fibroblasts of GC than in noncancerous tissues. The simultaneous expression of TNC and Twist1 in GC stromal fibroblasts was positively associated with tumor location, pT stage, lymph node metastasis and clinical stage. Moreover, patients with co‐expression of TNC and Twist1 had a poorer prognosis than either TNC or Twist1 positive in GC. Our study revealed that the simultaneous expression of TNC and Twist1 indicated the poorer prognosis of GC. Co‐targeting TNC and Twist1 confer significant clinical advantage, which offers a novel therapeutic target in GC.

Tenascin-c Knockdown Suppresses Vasculogenic Mimicry of Gastric Cancer by Inhibiting ERK- Triggered EMT

“…Recent studies demonstrated that TNC was strongly expressed and indicated poor prognosis in gastric cancer [16,20]. The present results con rmed that TNC was upregulated in gastric cancer tissues and patients with higher TNC levels had signi cantly shorter overall survival (OS) and relapse free survival (RFS) compared to those with low TNC expression, consistent with our single-center data.…”

“…However, it is speci cally upregulated during wound healing, chronic in ammation or cancer [19]. Recent studies have shown that the expression of TNC was signi cantly associated with pT stage, lymph node metastasis and distant metastasis in gastric cancer [20]. TNC was identi ed in inducing epithelial-to-mesenchymal (EMT) transition [21] and EMT has been found to play a key role in VM formation [9,22,23].…”

Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer

“…Several genes belonging to those pathways were overexpressed in DUSP6 depleted cells. One of them, Tenascin-C expression is upregulated and has been involved in gastric [15] and gastric GIST cancer progression [16], increased proliferation in pancreatic cancer [17] and is a prognostic determinant of colorectal cancer through induction of epithelial to mesenchymal transition and proliferation [18]. CCND2 gene has been shown to be targeted by expression of mir-4317 and miR-671-3p and related to inhibition of cancer progression in NSCLC [19].…”

Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

“…TNC in eCCA has not been reported. However, TNC presence in gastrointestinal malignancies such as pancreatic ductal [ 78 , 79 ], oesophageal [ 80 ], gastric [ 81 ], and colorectal [ 82 ] adenocarcinoma have been described.…”