The role of tar in Goeckerman therapy

Belsito, D. V.

doi:10.1001/archderm.118.5.319

Cited by 10 publications

(3 citation statements)

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“…Several mechanisms have been proposed to explain why Goeckerman treatment is so effective in psoriasis. The combination of tar and lights has been reported to be more effective than either therapy alone (21)(22)(23), although the role of tar has been debated (24,25). The intensity of the treatment, which could not be easily administered at home, may be a contributing factor.…”

Section: Discussionmentioning

confidence: 99%

Results of Goeckerman Treatment for Psoriasis in Children: A 21-Year Retrospective Review

Kortuem

Davis

Witman

et al. 2010

Pediatric Dermatology

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Goeckerman treatment has been used for the management of widespread psoriasis in children for several decades at Mayo Clinic. We aimed to review our institutional experience with the effectiveness of Goeckerman treatment for psoriasis in children. We retrospectively reviewed the records of pediatric patients who underwent Goeckerman treatment over a 21-year period (1983-2003). The main outcome measure was improvement in psoriasis. During the study period, 65 children received Goeckerman treatment for predominantly widespread, recalcitrant psoriasis. The mean age was 11.6 years (range, 3 mos to 18 yrs), and the female-to-male ratio was 2:1. Psoriasis improved in all patients: 55 patients (85%) had >80% clearance of their psoriasis. The only adverse effect was folliculitis, occurring in 27 patients (42%). Mean duration of follow-up was 2.6 years (range, 17 days-18.2 yrs); average duration of remission was 2.6 years (range, 2 mos-12.79 yrs). Goeckerman treatment is an effective treatment for widespread psoriasis in children.

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Section: Discussionmentioning

confidence: 99%

Results of Goeckerman Treatment for Psoriasis in Children: A 21-Year Retrospective Review

Kortuem

Davis

Witman

et al. 2010

Pediatric Dermatology

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“…Several studies compare tar with petrolatum in UV therapy and show no enhanced therapeutic benefit of the tar with erythemogenic doses of UV. [23][24][25][26][27][28] One modified Goeckerman regimen consists of the patient applying tar ointment at bedtime, followed by UV exposure in the morning after removal of tar from body surfaces. A study of 123 patients with psoriasis undergoing this regimen with daily UV irradiation and thrice daily tar ointment application for an average of 20 days demonstrated good to excellent results in 95% of patients with remission rates averaging 1.7 years with a range of 2 months to 8 years.…”

Section: Indicationsmentioning

confidence: 99%

Topical tar: Back to the future

Paghdal

Schwartz

2009

Journal of the American Academy of Dermatology

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“…Various combinations of therapeutic agents are used for the treatment of psoriasis patients (1). Goeckerman (2) reported the successful use of crude coal tar and ultraviolet radiation in 1925. Since then, UVB therapy has been used in combination with various agents.…”

Section: Introductionmentioning

confidence: 99%

Effects of Calcipotriol Cream and Ointment, Clobetasol Cream and Ointment and Tretinoin Cream on the Erythemogenicity of UVB

Fetil

İlknur

Altiner

et al. 2005

The Journal of Dermatology

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Various studies have shown the blocking effects of topical agents on UVB penetration, which can be used in combination with phototherapy. In this study, the photoprotective effects of 0.005% calcipotriol, 0.05% clobetasol-17-propionate, and 0.1% tretinoin, which can be used in combination with broad-band UVB, were investigated in an in vivo test. In a study group of 20 patients, phototests were performed to determine minimal erythema doses (MED) and the tests were repeated with thin (0.1 cc/25 cm2) and thick (0.3 cc/25 cm2) calcipotriol, clobetasol-17-propionate, and tretinoin in cream forms and sunscreen. After determining the MED, the test was repeated in another 20 patients with thin and thick calcipotriol and clobetasol-17-propionate in both cream and ointment forms and sunscreen. MED was increased with thin and thick applications of all agents. Moreover, the photoprotective effects of each agent increased with their thick applications compared with thin ones. The application of calcipotriol cream and ointment, clobetasol cream and ointment, and tretinoin cream, all of which can block UVB, is not recommended just before phototherapy.

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The role of tar in Goeckerman therapy

Cited by 10 publications

References 0 publications

Results of Goeckerman Treatment for Psoriasis in Children: A 21-Year Retrospective Review

Results of Goeckerman Treatment for Psoriasis in Children: A 21-Year Retrospective Review

Topical tar: Back to the future

Effects of Calcipotriol Cream and Ointment, Clobetasol Cream and Ointment and Tretinoin Cream on the Erythemogenicity of UVB

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