The role of T lymphocytes in patients with food-sensitive atopic dermatitis

Kondo, Naomi; Fukutomi, Osamu; Agata, Hiroatsu; Motoyoshi, Fumiaki; Shinoda, Seirou; Kobayashi, Yuki; Naoki, Katsuhiko; Kameyama, T.; Orii, Tadao

doi:10.1016/0091-6749(93)90272-h

Cited by 64 publications

(27 citation statements)

References 29 publications

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“…As a consequence, we were not able to further characterize the phenotype of peripheral blood cells reacting to b-LG. We found that proliferative responses were strongly reduced when blocking HLA-DQ and -DR molecules, in agreement with previous studies showing that allergens predominantly activate major histocompatibility complex-class II restricted CD4ϩ T cells (3,23,24). Furthermore, our findings are in line with previous reports demonstrating the presence of food-specific T lymphocytes also in nonallergic, healthy subjects (13,17,18,23,25).…”

Section: Discussionsupporting

confidence: 83%

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

et al. 2011

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Several studies analyzing the immune responses in patients with cow's milk allergy (CMA) have used T-cell lines or T-cell clones that require prolonged in vitro cell culturing and may result in a switched cell phenotype and function. We investigated immune responses to beta-lactoglobulin (b-LG) in peripheral blood mononuclear cells after a short in vitro antigen stimulation in children with acute CMA (both IgE-mediated and non-IgE-mediated forms) and in those who outgrew an IgE-mediated CMA. Healthy controls were also investigated. Peripheral blood mononuclear cells were assayed for IL-13, IFN-␥, IL-4, and IL-10. Although b-LG induced a cytokine production and/or cell proliferation almost in all children, included healthy controls, differences were observed among the four groups. Children with IgE-mediated CMA had a marked Th2-response, with high IL-13 production and proliferation, but low IFN-␥; by contrast, children with non-IgE-mediated CMA produced no, or very low, IL-13 and cell proliferation. Children, who outgrew CMA, showed a shift to a Th1-response, with reduced IL-13 and increased IFN-␥. IL-10-responses were high in all groups, with the highest level in healthy children; by contrast, IL-4 was undetectable in all children. This study highlights the use of shortly stimulated peripheral blood cells to investigate the food-induced immune responses. (Pediatr Res 70: 549-554, 2011)

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Section: Discussionsupporting

confidence: 83%

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

et al. 2011

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“…Our results support the observation that IgE-mediated re actions to OVA arc important in the pathogenesis of AD in patients with egg allergy [1], However, the results of this Characterization o f OVA-Specific T Cell Lines study arc at odds with a recent report by Kondo et al [9] which showed that PBMCs from egg-allergic AD patients produce IL-2 and lFN-yon OVA stimulation. Based on their data, they suggested that T ill-type T cells are involved in the development o f AD.…”

Section: F E K I T E W T S S N V M E E R K 277contrasting

confidence: 57%

“…These patients demonstrated a pruritic erythematous morbilliform rash followed by exacerbation of eczematous lesions on egg challenge. In contrast, Kondo et al [9] investigated cytokine production from PBMCs of AD patients presenting only a late cutaneous response to egg challenge. The important role of TI I2 cells in AD has directly been established by recent findings that housedust-mite-specific TH2-type T cells can be successfully cloned from affected skin as well as from peripheral blood in atopic patients with AD [10][11][12], Although Kondo et al [9] claimed the involvement of THl-type T cells, they also found an increase in CD23 expression on PBMCs after OVA stimulation.…”

Section: F E K I T E W T S S N V M E E R K 277mentioning

confidence: 99%

Establishment and Characterization of Ovalbumin-Specific T Cell Lines from Patients with Egg Allergy

Katsuki¹,

Shimojo²,

Honma³

et al. 1996

Int Arch Allergy Immunol

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In order to investigate T cell recognition of allergens in hen egg allergy, we have established 30 ovalbumin (OVA)-specifíc T cell lines (TCLs) from peripheral blood mononuclear cells of 6 patients with atopic dermatitis, who are positive for IgE antibodies to OVA and clinically allergic to hen egg, and characterized them for their cytokine production pattern. All TCLs we could study were mainly composed of CD4+ T cells. Most TCLs produced significant amounts of interleukin 4 (IL-4) and IL-5 but no or very little interferon γ on antigen stimulation, suggesting that these TCLs belong to TH2-type T cells. Restriction elements and epitope specificities were further studied on some TCLs. Antibody blocking of the proliferative responses of the TCLs to OVA indicated that HLA-DR are acting as the dominant restriction elements for these TCLs with minor contribution of HLA-DQ. By use of 187 overlapping synthetic peptides covering the whole sequence of OVA, at least 3 different T cell epitopes were identified.

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“…Sitokin ini diperkirakan memegang peran utama pada respons alergi. Tetapi alergi makanan yang menimbulkan DA dapat juga diperantarai oleh cell mediated immunity 6 Sedangkan alergi makanan yang diperankan oleh reaksi hipersenitivitas tipe II dan III jarang dilaporkan.…”

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Peran Alergi Makanan dan Alergen Hirup pada Dermatitis Atopik

Siregar

2016

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Sensitisasi makanan dan aeroalergen memegang peran pada patogenesis penyakit atopikseperti dermatitis atopik (DA), rinitis alergik dan asma. Dermatitis atopik merupakansuatu penyakit kronik yang tidak dapat disembuhkan 100% dan sering mengalamieksaserbasi, serta menimbulkan masalah pada orang tua dan dokter. Banyak faktor yangberperan pada DA, baik faktor eksogen atau endogen maupun kombinasi keduanya.Faktor genetik merupakan salah satu faktor yang berperan pada DA. Faktor eksogenseperti makanan aeroalergen banyak dilaporkan sebagai pencetus timbulnya DA. Masihterdapat perbedaan pendapat mengenai makanan sebagai penyebab tetapi terdapat buktibahwa bila makanan dihindarkan gejala dermatitis membaik. Susu sapi memprovokasigejala DA pada usia bayi1 dan 30% DA disebabkan alergi susu sapi2.Alergen hirup seperti tungau debu rumah berperan pada patogenesis DA, terutamapada anak; hal ini berdasarkan beberapa pengamatan klinis, uji kulit dan IgE spesifikyang tinggi serta terdapat perbaikan gejala klinis DA setelah penghindaran tungau deburumah.3 Alergen makanan lebih berpengaruh pada usia bayi kurang dari 1 tahunsedangkan aeroalergen pada usia di atas 2 tahun.4 H asil penelitian di Departemen IKARSCM menunjukkan bahwa DA pada anak dengan onset kurang dari 1 tahun yangtelah tersensitisasi telur dan aeroalergen akan meningkatkan risiko alergi saluran napasdi kemudian hari sampai sepuluh kali lipat

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The role of T lymphocytes in patients with food-sensitive atopic dermatitis

Cited by 64 publications

References 29 publications

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

Establishment and Characterization of Ovalbumin-Specific T Cell Lines from Patients with Egg Allergy

Peran Alergi Makanan dan Alergen Hirup pada Dermatitis Atopik

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