The role of surgical resection in the management of brain metastasis: a 17-year longitudinal study

Abstract

Surgical resection may accomplish satisfactory outcomes with technical advancement. The best indications for SR for brain metastasis are RPA I class, stable extracranial cancer, and a planned GTR of the tumour. Even with the advancements in adjuvant therapy, surgical resection plays a major role in the management of brain metastasis.

Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis

“…Eight retrospective cohort studies provided outcomes for 646 patients treated with WBRT (n = 408) or SRS (n = 238) following resection (Fig. 1) [5, 18, 20, 24–28]. The most common primary tumor histologies were non-small cell lung cancer and colon cancer.…”

“…Data regarding local recurrence was available in five out of the eight studies included in our review [5, 18, 20, 26, 27]. The local recurrence incidence ranged from 0 to 60% in patients treated with adjuvant SRS and from 11 to 24% in patients treated with adjuvant WBRT.…”

“…Brain metastases are an increasingly common complication of systemic cancers and represent a significant source of morbidity and mortality in cancer patients [1–5]. Approximately, 20–40% of cancer patients with primary extracranial cancer will develop brain metastases during the course of their disease [6].…”

“…Resection allows for histopathological examination of the tissue and has been shown to improve neurological symptoms, functional independence, and survival [5]. Moreover, several studies found that when resection was followed by adjuvant WBRT, it resulted in improved intracranial tumor control and lower rates of neurologic deaths compared to resection alone [9–13].…”

Evaluation of the reduced scalp dose at Volumetric Modulated Arc Therapy(VMAT)

“…화, 환자의 삶의 질 향상, 생존기간 연장에 효과적인 방법 은 전뇌조사이다 [8,9]. 전뇌조사는 뇌 전체에 대해 수정체 를 포함한 안면부 및 경추부를 차폐하여 대향 2문 측방향 조사를 실시하는 것이다 [10].…”