The role of surface science in bioengineered materials

Tirrell, Matthew; Kokkoli, Efrosini; Biesalski, Markus

doi:10.1016/s0039-6028(01)01548-5

Cited by 423 publications

(344 citation statements)

References 140 publications

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“…Surface modifications play an important role in biomedical devices, biosensors, biomaterials, and implants [287][288][289][290][291][292]. In most biomedical applications, surfaces are the primary "agents" that come into contacts with biomolecules, body fluids, cells, and tissues.…”

Section: Surface Engineeringmentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

280

231

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Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers and other biopolymers based on repetitive peptide motifs. Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.

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Section: Surface Engineeringmentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

280

231

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“…2 HAp-collagen composites are biodegradable and good matrices for bone cell attachment and proliferation, as well as new bone formation. 4 Several non-collagenous proteins have been also associated with HAp. Specifically, the growth of the bone is controlled by naturally evolved proteins, [5][6][7] and malfunction of these proteins may lead to severe skeletal diseases.…”

Section: Introductionmentioning

confidence: 99%

Mineralization of DNA into nanoparticles of hydroxyapatite

et al. 2014

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“…20,33,35,76 Such nonfouling surfaces, however, are limiting for numerous biomedical applications, for which selected interactions with the biological media are required. Alternatively, controlled derivatization of bioinert surfaces with small molecules, 15,41,49 polypeptides 9,23,51,63,79 or oligo and polysaccharides 60 yields interfaces that mediate biospecific interactions and suppress nonspecific interactions.…”

Section: Introductionmentioning

confidence: 99%

Surface-Bound Proteins with Preserved Functionality

et al. 2009

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Abstract-Biocompatibility of materials strongly depends on their surface properties. Therefore, surface derivatization in a controllable manner provides means for achieving interfaces essential for a broad range of chemical, biological, and medical applications. Bioactive interfaces, while manifesting the activity for which they are designed, should suppress all nonspecific interaction between the supporting substrates and the surrounding media. This article describes a procedure for chemical derivatization of glass and silicon surfaces with polyethylene glycol (PEG) layers covalently functionalized with proteins. While the proteins introduce the functionality to the surfaces, the PEGs provide resistance against nonspecific interactions. For formation of aldehyde-functionalized surfaces, we coated the substrates with acetals (i.e., protected aldehydes). To avoid deterioration of the surfaces, we did not use strong mineral acids for the deprotection of the aldehydes. Instead, we used a relatively weak Lewis acid for conversion of the acetals into aldehydes. Introduction of a,x-bifunctional polymers into the PEG layers, bound to the aldehydes, allowed us to covalently attach green fluorescent protein and bovine carbonic anhydrase to the surfaces. Spectroscopic studies indicated that the surface-bound proteins preserve their functionalities. The surface concentrations of the proteins, however, did not manifest linear proportionality to the molar fractions of the bifunctional PEGs used for the coatings. This finding suggests that surface-loading ratios cannot be directly predicted from the compositions of the solutions of competing reagents used for chemical derivatization.

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The role of surface science in bioengineered materials

Cited by 423 publications

References 140 publications

Peptide-based biopolymers in biomedicine and biotechnology

Peptide-based biopolymers in biomedicine and biotechnology

Mineralization of DNA into nanoparticles of hydroxyapatite

Surface-Bound Proteins with Preserved Functionality

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