The Role of Substance P in Chronic Low Back Pain (CLBP)

Rachmawati, Yusnita

doi:10.18860/jip.v4i2.8163

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…SP has a pro-inflammatory effect on immune cells and epithelial cells that play a role in inflammatory diseases of the respiratory, gastrointestinal, and musculoskeletal systems. Many substances induce the release of neuropeptides from sensory nerves in the lungs, including allergens, histamine, prostaglandins, and leukotrienes [18].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Pregabalin Levels on Pain and Substance P Level Post-Cesarean Section

Gaus

Harahap

Ahmad

et al. 2023

Open Access Maced J Med Sci

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BACKGROUND: Post-operative pain is a very important problem faced by post-operative patients. Antihyperalgesia is caused by the inhibition of the neurotransmitter glutamate and substance P (SP) by pregabalin. This study aimed to compare the effect of preventive administration of 50 mg oral pregabalin and 1 g paracetamol with 75 mg oral pregabalin and 1 g intravenous paracetamol on Numeric Rating Scale (NRS) scores and SP levels after cesarean section with spinal anesthesia. AIM: The objective of the study was to compare the effect of preventive administration of 50 mg oral pregabalin and 1 g paracetamol with 75 mg oral pregabalin and 1 g intravenous paracetamol on NRS scores and SP levels after cesarean section with spinal anesthesia. METHODS: This study used a double-blind randomized trial design. Samples were selected randomly and consecutively from the entire population that met the inclusion criteria. There were a total of 30 samples. SP levels were measured 2 h before cesarean section. The study drug was administered by mouth with a sip of water 1 h before the expected time of the surgical incision. SP levels were checked at the 4th h (SP 1) and 6th h (SP 2) postoperatively. The assessment of the degree of pain using the NRS was carried out at 2 h, 4 h, 6 h, 12 h, and 24 h postoperatively. This study used the Mann–Whitney U-test to compare both the levels of SP and NRS between the two groups. RESULTS: The results of this study showed that there was a significant difference in the NRS scores between the 50 mg and 75 mg pregabalin groups (p < 0.05). In the 75 mg pregabalin group, the NRS scores were lower than in the 50 mg pregabalin group in patients undergoing CS surgery under spinal anesthesia. There was a significant difference in SP levels between the 50 mg and 75 mg pregabalin groups (p < 0.05). SP levels in the 50 mg pregabalin group increased at 4 h and 6 h postoperatively, while in the 75 mg pregabalin group, it tended to decrease at 4 h and 6 h postoperatively. CONCLUSION: The quiescent and mobile NRS scores in the 75 mg pregabalin group were lower than the 50 mg pregabalin group with a combination of 1 g intravenous paracetamol after SC surgery. SP levels in the 75 mg pregabalin group decreased compared to the 50 mg pregabalin group with a 1 g intravenous paracetamol combination which experienced an increase after CS surgery. Pregabalin 75 mg is recommended for preventive use in CS surgery.

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Section: Discussionmentioning

confidence: 99%

The Effect of Pregabalin Levels on Pain and Substance P Level Post-Cesarean Section

Gaus

Harahap

Ahmad

et al. 2023

Open Access Maced J Med Sci

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“…8,9,10 The aim of pain management is to improve the quality of life of the patients by relieving pain and helping them to gain proper functioning. 11 Unrelieved and long-standing pain may substantially affect psychological well-being. 12 Corticosteroid injections are frequently administered to treat pain associated with rheumatic and musculoskeletal disorders and have been registered as a localized treatment of varying conditions, such as rheumatoid arthritis, tendinopathy, bursitis, synovitis, epicondylitis, ganglion condition, neuromas, fasciitis, back pain, and entrapment syndrome.…”

Section: Introductionmentioning

confidence: 99%

Hypopigmentation and subcutaneous fat atrophy associated with corticosteroid injection: a case report

Prihatsari¹,

Hidayati²,

Damayanti³

et al. 2021

Anaesth. pain intensive care

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Corticosteroid injections have been shown to be an effective treatment modality in many of the musculoskeletal and rheumatologic conditions. Yet, the potential adverse effects of corticosteroid injections have not been given much attention. One of the potential adverse effects that should be considered by clinicians is skin hypopigmentation and subcutaneous fat atrophy. Although it is a rare side effect, it may have cosmetically unpleasant effect. The aim of this case report is to highlight the importance of providing adequate information to the patients regarding these dermal adverse effects of corticosteroid injections. We report the case of a 31-year-old female who suffered from skin hypopigmentation and subcutaneous fat atrophy after triamcinolone injection given for de Quervain’s tenosynovitis. Key words: de Quervain’s tenosynovitis; Fat atrophy; Hypopigmentation; Corticosteroid injections; Adverse effects; Pain Citation: Prihatsari F, Hidayati HB, Damayanti D, Budisulistyo T. Hypopigmentation and subcutaneous fat atrophy associated with corticosteroid injection: a case report. Anaesth. pain intensive care 2021;25(6):807–811; DOI: 10.35975/apic.v25i6.1708

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The Role of Substance P in Chronic Low Back Pain (CLBP)

Cited by 2 publications

References 54 publications

The Effect of Pregabalin Levels on Pain and Substance P Level Post-Cesarean Section

The Effect of Pregabalin Levels on Pain and Substance P Level Post-Cesarean Section

Hypopigmentation and subcutaneous fat atrophy associated with corticosteroid injection: a case report

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