The Role of Stress Responses in Determining Cell Fate Following Exposure to Ultraviolet Radiation

Cridland, N. A.; Martin, Manuela; Stevens, Kirk L.; Baller, C. A.; Pearson, A. J.; Driscoll, C.M.H.; Saunders, Richard D. E.

doi:10.1093/oxfordjournals.rpd.a033239

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Cell Viability Test Using Fcmeoh Oxidation Upon Uvc Radiation1

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2001

2009

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“…After a dose of 16 J m À2 , only 15% of the HeLa cells generated positive feedback for FcMeOH oxidation. Similar effects of UVC radiation on the survival rate of HeLa cells was reported previously [44]. Exposure of mammalian cells to UV radiation is known to damage the cellular DNA, leading to either cell mutation or death [45,46].…”

Section: Cell Viability Test Using Fcmeoh Oxidation Upon Uvc Radiationsupporting

confidence: 83%

Scanning electrochemical microscopy of HeLa cells – Effects of ferrocene methanol and silver ion

Xiao

Bard

2009

Journal of Electroanalytical Chemistry

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Section: Cell Viability Test Using Fcmeoh Oxidation Upon Uvc Radiationsupporting

confidence: 83%

Scanning electrochemical microscopy of HeLa cells – Effects of ferrocene methanol and silver ion

Xiao

Bard

2009

Journal of Electroanalytical Chemistry

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Modulation of radiation-induced protein kinase C activity by phenolics

Varadkar

Dubey²,

Krishna³

et al. 2001

J. Radiol. Prot.

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Natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C (PKC) isolated from the liver cytosol and the particulate fraction of unirradiated mice and mice irradiated at 5 Gy. Following irradiation, the PKC activity was found to be increased in both cytosolic and particulate fractions. Curcumin, ellagic acid and quercetin were effective in inhibiting radiation-induced PKC activity. Curcumin and ellagic acid were found to be more inhibitory towards radiation-induced PKC activity, while quercetin was the least effective. Curcumin was found to inhibit the activated cytosolic and particulate PKC at very low concentrations. Activation of PKC is one of the means of conferring radioresistance on a tumour cell. Suppression of PKC activity by phenolics may be one of the means of preventing the development of radioresistance following radiotherapy.

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The Role of Stress Responses in Determining Cell Fate Following Exposure to Ultraviolet Radiation

Cited by 2 publications

References 0 publications

Scanning electrochemical microscopy of HeLa cells – Effects of ferrocene methanol and silver ion

Scanning electrochemical microscopy of HeLa cells – Effects of ferrocene methanol and silver ion

Modulation of radiation-induced protein kinase C activity by phenolics

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