Modulation of radiation-induced protein kinase C activity by phenolics

Varadkar, Prajakta; Dubey, Poonam; Krishna, M. Bala; Verma, Naresh C.

doi:10.1088/0952-4746/21/4/304

Cited by 29 publications

(16 citation statements)

References 51 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a similar manner to that shown by chemotherapy, some studies have evaluated the combined effect of quercetin and radiotherapy [98][99][100][101][102]. In 1997 a study which investigated the combined effect of quercetin with X-rays on Reuber H35 hepatoma cells was carried out [102].…”

Section: Combination Therapymentioning

confidence: 99%

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

Brito¹,

Ribeiro²,

Abrantes

et al. 2015

CMC

134

View full text Add to dashboard Cite

Abstract:Cancer is a problem of global importance, since the incidence is increasing worldwide and therapeutic options are generally limited. Thus, it becomes imperative to find new therapeutic targets as well as new molecules with therapeutic potential for tumors. Flavonoids are polyphenolic compounds that may be potential therapeutic agents. Several studies have shown that these compounds have a higher anticancer potential. Among the flavonoids in the human diet, quercetin is one of the most important. In the last decades, several anticancer properties of quercetin have been described, such as cell signaling, pro-apoptotic, anti-proliferative and anti-oxidant effects, growth suppression. In fact, it is now well known that quercetin has diverse biological effects, inhibiting multiple enzymes involved in cell proliferation, as well as, in signal transduction pathways. On the other hand, there are also studies reporting potential synergistic effects when combined quercetin with chemotherapeutic agents or radiotherapy. In fact, several studies which aim to explore the anticancer potential of these combined treatments have already been published, the majority with promising results. Actually it is well known that quercetin can act on the chemosensitization and radiosensitization but also as chemoprotective and radioprotective, protecting normal cells of the side effects that results from chemotherapy and radiotherapy, which obviously provides notable advantages in their use in anticancer treatment. Thus, all these data indicate that quercetin may have a key role in anticancer treatment. In this context, this review is focused on the relationship between flavonoids and cancer, with special emphasis on the role of quercetin.

show abstract

Section: Combination Therapymentioning

confidence: 99%

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

Brito¹,

Ribeiro²,

Abrantes

et al. 2015

CMC

134

View full text Add to dashboard Cite

show abstract

“…Activation of PKC is one of the means of conferring radioresistance on a tumour cell. Suppression of PKC activity by Quercetin may be one of the means of preventing the development of radioresistance following radiotherapy 101 .…”

mentioning

confidence: 99%

Quercetin: A Versatile Flavonoid

Lakhanpal

Kumar²

2007

Internet Journal of Medical Update - EJOURNAL

231

198

View full text Add to dashboard Cite

Associative evidence from observational and intervention studies in human subjects shows that a diet including plant foods (particularly fruit and vegetables rich in antioxidants) conveys health benefits. There is no evidence that any particular nutrient or class of bioactive substances makes a special contribution to these benefits. Flavonoids occur naturally in fruits, vegetables and beverages such as tea and wine. Quercetin is the major flavonoid which belongs to the class called flavonols. Quercetin is found in many common foods including apples, tea, onions, nuts, berries, cauliflower, cabbage and many other foods. Quercetin provides many health promoting benefits, including improvement of cardiovascular health, eye diseases, allergic disorders, arthritis, reducing risk for cancers and many more. The main aim of this review is to obtain a further understanding of the reported beneficial health effects of Quercetin, its pharmacological effects, clinical application and also to evaluate its safety.

show abstract

“…Phenolic phytochemicals like curcumin enhance the radiation effects in the PC-3, prostate cancer cell line [35]. Curcumin also acts as a radio-sensitizer and increases the effect of gamma-radiation on hamster ovary cells [36] and potentially prevents radio-resistance to irradiation in experimental animals [37].…”

Section: Discussionmentioning

confidence: 99%

2-deoxy-D-glucose combined with ferulic acid enhances radiation response in non-small cell lung carcinoma cells

Reddy

Prasad

2011

Open Life Sciences

View full text Add to dashboard Cite

Abstract:The present study was undertaken to investigate the radiosensitizing effects of 2-deoxy-D-glucose (2DG), a glycolytic inhibitor, and ferulic acid (FA), a phenolic prooxidant, in relatively radioresistant human non-small cell lung carcinoma cells (NCI-H460). NCI-H460 cells were treated with 4 mM 2DG and/or 53.8 μM FA for 24 h and then exposed to 2 Gy irradiation. Compared to cells that were 2 Gy-irradiated alone (50%), FA and 2DG with radiation (FA+2DG+IR) showed additional decrease in cell viability (15%). This has been further validated by decreased (86%) colony formation in 2DG+FA+IR group compared to 2DG (29%), FA (24%) and IR (37%) group alone. Increased apoptotic cells (84%) in 2DG+FA+IR group further confirm the radiosensitizing property of 2DG or FA. In NCI-H460 cells 2DG decreased NADPH levels (10%) and FA increased ROS levels leading to enhanced oxidative damage in the 2DG+FA+IR group. This was reflected as altered mitochondrial membrane potential, increased lipid peroxidative markers (TBARS), DNA damage and decreased intracellular glutathione (GSH) levels in combined treatment groups when compared to radiation or 2DG or FA treatment alone. The present study suggests that FA and 2DG act by increasing oxidative damage in NCI-H460 cells.

show abstract

Modulation of radiation-induced protein kinase C activity by phenolics

Cited by 29 publications

References 51 publications

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

Quercetin: A Versatile Flavonoid

2-deoxy-D-glucose combined with ferulic acid enhances radiation response in non-small cell lung carcinoma cells

Contact Info

Product

Resources

About