The Role of Spinal Cord Motoneurons in the Mechanisms of Development of Low-Gravity Motor Syndrome

Islamov, R. R.; Tyapkina, O. V.; Никольский, Е. Е.; Kozlovskaya, I. B.; Григорьев, А. И.

doi:10.1007/s11055-014-0045-9

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…The complex of changes occurring in human motor function under the conditions of real or simulated microgravity is called hypogravitational motor syndrome ( Kozlovskaya et al, 1988 ), and it is defined by a deficit in vestibular, proprioception, and support afferent activity ( Pechenkova et al, 2019 ), and substantial alterations in the functional (e.g., atony, a decline in speed-force qualities) and structural (e.g., atrophy and a phenotype deterioration) characteristics of skeletal muscles ( Kozlovskaya et al, 1988 ; Kozlovskaya and Kirenskaya, 2004 ; Koppelmans et al, 2017 ; Amirova et al, 2020 ). In experiments with animal models it was also shown that a hindlimb suspension in rats results in nerve fiber demyelinization, which in turn may play a role in the development of hypogravitational motor syndrome ( Islamov et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

NAIAD-2020: Characteristics of Motor Evoked Potentials After 3-Day Exposure to Dry Immersion in Women

Nosikova

Riabova

Amirova

et al. 2021

Front. Hum. Neurosci.

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As female astronauts participate in space flight more and more frequently, there is a demand for research on how the female body adapts to the microgravity environment. In particular, there is very little research on how the neuromuscular system reacts to gravitational unloading in women. We aimed to estimate changes in motor evoked potentials (MEPs) in the lower leg muscles in women after 3-day exposure to Dry Immersion (DI), which is one of the most widely used ground models of microgravity. Six healthy female volunteers (mean age 30.17 ± 5.5 years) with a natural menstrual cycle participated in this experiment. MEPs were recorded from the gastrocnemius and soleus muscles twice before DI, on the day of DI completion, and 3 days after DI, during the recovery period. To evoke motor responses, transcranial and trans-spinal magnetic stimulation was applied. We showed that changes in MEP characteristics after DI exposure were different depending on the stimulation site, but were similar for both muscles. For trans-spinal stimulation, MEP thresholds decreased compared to baseline values, and amplitudes, on the contrary, increased, resembling the phenomenon of hypogravitational hyperreflexia. This finding is in line with data observed in other experiments on both male and female participants. MEPs to transcranial stimulation had an opposing dynamic, which may have resulted from the small group size and large inter-subject variability, or from hormonal fluctuations during the menstrual cycle. Central motor conduction time remained unchanged, suggesting that pyramidal tract conductibility was not affected by DI exposure. More research is needed to explore the underlying mechanisms.

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Section: Introductionmentioning

confidence: 99%

NAIAD-2020: Characteristics of Motor Evoked Potentials After 3-Day Exposure to Dry Immersion in Women

Nosikova

Riabova

Amirova

et al. 2021

Front. Hum. Neurosci.

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show abstract

“…Thus, skeletal muscle plasticity depends on the condition of the different inputs to motor units. In light of this assumption and based on our earlier studies of the neuromuscular synapse, peripheral nerve, and spinal cord in a rat model of hypogravity [hind limb unloading model (HUM)] (Chelyshev et al, 2014; Islamov et al, 2015), we made a supposition that HMS pathogenesis is invoked by spinal motor neurons.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

et al. 2019

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The hypogravity motor syndrome (HMS) is one of the deleterious impacts of weightlessness on the human body in orbital space missions. There is a hypothesis that disorders of musculoskeletal system as part of HMS arise in consequence of changes in spinal motor neurons. The study was aimed at bioinformatic analysis of transcriptome changes in lumbar spinal cords of mice after a 30-day spaceflight aboard biosatellite Bion-M1 (space group, S) and subsequent 7-day readaptation to the Earth’s gravity (recovery group, R) when compared with control mice (C group) housed in simulated biosatellite conditions on the Earth. Gene ontology and human phenotype ontology databases were used to detect biological processes, molecular functions, cellular components, and human phenotypes associated with HMS. Our results suggest resemblance of molecular changes developing in space orbit and during the postflight recovery to terrestrial neuromuscular disorders. Remarkably, more prominent transcriptome changes were revealed in R vs. S and R vs. C comparisons that are possibly related to the 7-day recovery period in the Earth’s gravity condition. These data may assist with establishment of HMS pathogenesis and proposing effective preventive and therapeutic options.

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Comparing effects of microgravity and amyotrophic lateral sclerosis in the mouse ventral lumbar spinal cord

Yoshikawa

Ishikawa

et al. 2022

Molecular and Cellular Neuroscience

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The Role of Spinal Cord Motoneurons in the Mechanisms of Development of Low-Gravity Motor Syndrome

Cited by 4 publications

References 25 publications

NAIAD-2020: Characteristics of Motor Evoked Potentials After 3-Day Exposure to Dry Immersion in Women

NAIAD-2020: Characteristics of Motor Evoked Potentials After 3-Day Exposure to Dry Immersion in Women

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

Comparing effects of microgravity and amyotrophic lateral sclerosis in the mouse ventral lumbar spinal cord

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