The Role of Soluble Interleukin (IL)‐6 Receptor in Mediating the effects of IL‐6 on Matrix Metalloproteinase‐1 and Tissue Inhibitor of Metalloproteinase‐1 Expression by Gingival Fibroblasts

Abstract

These data strongly suggest that future clinical studies investigating the role of IL-6 in periodontal disease must also determine the levels of sIL-6r within the periodontal tissues.

Interleukin-6 Released from Fibroblasts Is Essential for Up-regulation of Matrix Metalloproteinase-1 Expression by U937 Macrophages in Coculture

“…8 and 9), this finding would suggest that IL-6 released by the coculture stimulates MMP-1 expression by U937 cells but not fibroblasts. Actually this notion is consistent with the report by Irwin et al (29) showing that the addition of IL-6 up to the concentration of 1,000 ng/ml to gingival fibroblasts had no effect on MMP-1 expression unless the soluble IL-6 receptor was used. It is most likely that lack of soluble IL-6 receptor in our coculture system is the reason that no MMP-1 up-regulation in fibroblasts was observed.…”

Expression, polymorphism and methylation pattern of interleukin-6 in periodontal tissues

“…Among several kinds of cytokines involved in periodontal disease, the interleukin-6 (IL-6) has been shown increased in the gingival crevicular fluids and in the gingival tissues of individuals with periodontitis (Takahashi et al 1994;Armitage 1996;Offenbacher 1996). The IL-6 is considered an inhibitor of bone formation and plays an important role in development of disease (Sodek and McKee 2000;Irwin et al 2002;Mercado et al 2003).…”

A influência de contraceptivos orais combinados na condição periodontal

“…Pacientes com periodontite refratária apresentam níveis elevados de IL-6 no fluido crevicular gengival e nos sítios com doença periodontal. Diversos estudos (Bartold e Haynes, 1991;Geivelis, Turner et al, 1993;Takahashi, Takashiba et al, 1994;Irwin, Myrillas et al, 2002) relataram que células endoteliais, macrófagos e fibroblastos contribuem para a destruição periodontal através da produção de IL-6. Esta interleucina também influencia na produção de outro mediador inflamatório chamado de inibidor tecidual de metaloproteinases (TIMP), o qual bloqueia a atividade de algumas enzimas proteolíticas que são estimuladas pela IL-1.…”

“…Observaram que a IL-1 estimula aumento na expressão de várias quimiocinas, metaloproteinases da matrix (MMPs), e moléculas de adesão de leucócitos e células endoteliais (Birkedal-Hansen, 1993;Morris, Harper et al, 1993;Wahl e Corcoran, 1993;Graves, Delima et al, 1998;Irwin, Myrillas et al, 2002). A progesterona e/ou estradiol, por sua vez, promoveram redução significativa na expressão de todos os mencionados acima.…”