The role of soluble fiber intake in patients under highly effective lipid-lowering therapy

Abstract

BackgroundIt has been demonstrated that statins can increase intestinal sterol absorption. Augments in phytosterolemia seems related to cardiovascular disease.ObjectiveWe examined the role of soluble fiber intake in endogenous cholesterol synthesis and in sterol absorption among subjects under highly effective lipid-lowering therapy.DesignIn an open label, randomized, parallel-design study with blinded endpoints, subjects with primary hypercholesterolemia (n = 116) were assigned to receive during 12 weeks, a daily dose of 25 g of fiber (corresponding to 6 g of soluble fibers) plus rosuvastatin 40 mg (n = 28), rosuvastatin 40 mg alone (n = 30), sinvastatin 40 mg plus ezetimibe 10 mg plus 25 g of fiber (n = 28), or sinvastatin 40 mg plus ezetimibe 10 mg (n = 30) alone.ResultsThe four assigned therapies produced similar changes in total cholesterol, LDL-cholesterol, and triglycerides (p < 0.001 vs. baseline) and did not change HDL-cholesterol. Fiber intake decreased plasma campesterol (p < 0.001 vs. baseline), particularly among those patients receiving ezetimibe (p < 0.05 vs. other groups), and β-sitosterol (p = 0.03 vs. baseline), with a trend for lower levels in the group receiving fiber plus ezetimibe (p = 0.07). Treatment with rosuvastatin alone or combined with soluble fiber was associated with decreased levels of desmosterol (p = 0.003 vs. other groups). Compared to non-fiber supplemented individuals, those treated with fibers had weight loss (p = 0.04), reduced body mass index (p = 0.002) and blood glucose (p = 0.047).ConclusionAmong subjects treated with highly effective lipid-lowering therapy, the intake of 25 g of fibers added favorable effects, mainly by reducing phytosterolemia. Additional benefits include improvement in blood glucose and anthropometric parameters.

In vivo effect of oat cereal β‐glucan on metabolic indexes and satiety‐related hormones in diet‐induced obesity C57‐Bl mice

“…Beta glucan (β‐glucan) is a soluble fiber readily available from oat and barley grains that has been gaining interest due to its multiple functional and bioactive properties. Several randomized controlled trials revealed anti obesity effect of dietary fiber .…”

Stability of black grass jelly (Mesona chinensis) probioticated by encapsulation of Lactobacillus plantarum Mar8 with agar and gum Arabic

“…According to Handayani et al (2017), this jelly was known as healthy food or drink because it contained high concentration of soluble fiber and lowcalorie. High soluble fiber had been proven to reduce lipid profiles (Ramos et al 2011;Wahyono et al 2015;Handayani et al 2017). The Indonesian Ministry of Health's Nutrition Directorate (year of 1992) stated that 100 grams of black jelly contained 6.23 grams of crude fiber.…”

Black Grass Jelly (Mesona Palustris Bl) Effervescent Powder has Anti-Dyslipidemia in High Cholesterol Diet-Fed Rats and Antioxidant Activity

“…Black grass jelly (Mesona palustris BL), or black cincau, has a high concentration insoluble fiber. High soluble fiber has been proven to lower lipid profiles (Ramos et al, 2011). Black grass jelly effervescent powder (BCRP) was developed due to its popularity as beverages for a human.…”