The role of sleep duration in diabetes and glucose control

Alnaji, Alia; Law, Graham

doi:10.1017/s002966511600063x

Cited by 23 publications

(12 citation statements)

References 42 publications

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“…A significant association between a short sleep duration and prediabetes is consistent with many previous studies[ 1 , 3 , 5 , 6 - 13 , 15 , 16 ]. This association could be explained by physiological mechanisms, such as insulin resistance[ 27 , 28 ], decreased leptin levels, increased ghrelin levels and inflammation, sympathetic nervous system activation, and oxidative stress[ 29 ]. This association could also be explained by behavioral mechanisms, such as increased food intake, and unfavorable lifestyles, such as smoking and sedentary behavior[ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Age-dependent changes in the association between sleep duration and impaired glucose metabolism

Nakajima¹,

Suwa²,

Toyama³

2017

WJD

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AIMTo investigate whether the association between sleep duration and impaired glucose metabolism varies among younger and older populations.METHODSWe reviewed data of self-reported habitual sleep duration per night, HbA1c levels, and clinically relevant factors in a cross-sectional checkup database of 75472 Japanese from the general population aged 20-79 years (51695 men and 23777 women). Associations of prediabetes (HbA1c ≥ 5.7% and/or diabetic pharmacotherapy) or diabetes (HbA1c ≥ 6.5% and/or diabetic pharmacotherapy) with short and long sleep durations compared with a reference sleep duration (7 h) were investigated by multivariate logistic regression analysis. We controlled for potential relevant confounders, including age, sex, and work duration per day according to younger and older subjects.RESULTSAs age advanced, sleep duration became longer and this increase in the 40s and 50s was two times greater in men than in women. This finding was accompanied by a deterioration in HbA1c levels. In subjects aged younger than 40 years (n = 32929), HbA1c levels were inversely and linearly correlated with sleep duration in both sexes. However, in subjects aged 40 years or older (n = 42543), HbA1c levels showed a non-linear relationship against sleep duration with a nadir at 7 h. Multivariate logistic regression analysis showed that in younger subjects, short durations of sleep (≤ 5 h and 6 h) were positively associated with prediabetes (both P < 0.001), but a long duration of sleep (≥ 8 h) was inversely associated with prediabetes (P < 0.001). These associations remained significant after adjustment for relevant confounders, including age, sex, and work duration per day (ORs = 1.20, 95%CI: 1.05-1.37, P < 0.001; ORs = 1.12, 95%CI: 1.02-1.24, P < 0.05; and ORs = 0.84, 95%CI: 0.72-0.99, P < 0.05, respectively). In contrast, in older subjects, besides an association of prediabetes with a short duration of sleep (≤ 5 h) (ORs = 1.12, 95%CI: 1.03-1.21, P < 0.01), diabetes was significantly associated with a long duration of sleep (≥ 8 h) (ORs = 1.11, 95%CI: 1.02-1.25, P < 0.05).CONCLUSIONA short sleep duration may be associated with prediabetes throughout life. However, the association between a long sleep duration and glucose metabolism can change with aging.

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Section: Discussionmentioning

confidence: 99%

Age-dependent changes in the association between sleep duration and impaired glucose metabolism

Nakajima¹,

Suwa²,

Toyama³

2017

WJD

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“…Abnormal glucose metabolism have been linked to disturbances of different aspects of sleep, including sleep duration, quality, respiratory function during sleep, and circadian timing 41 . Both short and long sleep durations are associated with worse glucose control in people with diabetes 42 .…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise and dietary intervention on serum metabolomics in men with insomnia symptoms: a 6-month randomized-controlled trial

Zhang

Wang

et al. 2020

Preprint

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Background: Accumulating evidences have shown that lifestyle interventions such as exercise and diet are associated with improved sleep quality. However, the underlying molecular mechanisms remain unclear. Assessing exercise and diet intervention associated changes in circulating metabolomics profile in people with insomnia symptoms may help to identify molecular biomarkers that may link lifestyle changes to improved sleep outcomes. Methods:The present study is a part of a 6-month randomized lifestyle intervention on sleep disorder subjects. Seventy-two Finnish men (aged: 51.6 ± 10.1 years; body mass index, BMI: 29.3 ± 3.9 kg/m 2 ) with chronic insomnia symptoms who were assigned into different intervention groups completed this study (exercise n = 24, diet n = 27 and control n = 21). The exercise group was assigned to a progressive aerobic exercise training with intensity of 60 -75% of estimated maximum heart rate, 3 -5 times a week. The diet group aimed to reduce their total energy intakes by 300 to 500 kcal per day for the first three months. The control group were advised to maintain their current lifestyle. Sleep was assessed by using a non-contact sleep monitoring devise (Beddit sleep tracker). Blood samples were collected in the morning between 7:00 and 9:00 a.m. after overnight fasting. Gas Chromatography Time-Of-Flight Mass Spectrometry (GC-TOF-MS) method was used to determine the serum metabolites.Results: Twenty-one metabolites were significantly changed in the exercise group, thirty-three metabolites in the diet group and five metabolites in the control group after intervention, respectively. The differential metabolites after exercise intervention were mainly related to glycerolipids and carbohydrates metabolism, while dietary intervention altered mainly amino acids metabolism and fatty acids metabolism related metabolites. We subsequently assessed the change of those metabolites with the change of sleep parameters and found that decreased alpha-ketoisocaproic acid (r = -0.52, p = 0.026) was correlated with improved sleep efficiency (SE) in the exercise group. Change of 3-hydroxybutric acid (r = -0.47, p = 0.025) and D-glucopyranose (r = -0.54, p = 0.006) correlated negatively with SE in the diet group. On the other hand, oxalic acid (r = 0.49, p = 0.021), D-glucopyranose (r = 0.43, p = 0.048), 4-deoxyerythronic acid (r = 0.60, p = 0.004) and tagatose (r = 0.51, p = 0.016) correlated positively with change of SOL, and 2-keto-isovaleric acid (r = 0.45, p = 0.029) correlated with TST in the diet group. : medRxiv preprint Conclusion: In conclusion, this study identified circulating metabolites that may represent a part of a biological mechanism through which lifestyle interventions are associated with improved sleep quality in people with insomnia. : medRxiv preprint associations between serum metabolites and sleep quality after a randomized controlled six-month exercise or diet intervention in men with insomnia symptoms.

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“…Several studies have shown a U-shape relationship between the duration of sleep and risk of T2DM ( 56 – 58 ), with the lowest risk among those who slept 7–8 h per night ( 59 ). Compared with 7 h of sleep, the risk for developing diabetes ranged between 1.47 and 1.95 for shorter sleep duration and between 1.4 and 3.12 for longer sleep duration ( 60 ). Other studies have shown positive association between long, but not short, sleep duration and diabetes ( 61 , 62 ).…”

Section: Discussionmentioning

confidence: 99%

Association between Sleep Patterns and Health in Families with Exceptional Longevity

et al. 2017

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BackgroundSleep patterns such as longer sleep duration or napping are associated with poor health outcomes. Although centenarians and their offspring demonstrate a delayed onset of age-related diseases, it is not known whether they have healthier sleep patterns or are protected against the negative effects of sleep disturbances.MethodsData on sleep patterns and health history were collected from Ashkenazi Jewish subjects of the Longevity Genes Project using standardized questionnaires. Participants included individuals with exceptional longevity (centenarians) with preserved cognition (n = 348, median age 97 years), their offspring (n = 513, median age 69 years), and controls (n = 199) age-matched to the offspring. Centenarians reported on their sleep patterns at age 70, while the offspring and controls on their current sleep patterns. Biochemical parameters were measured at baseline. Models were adjusted for age, sex, BMI, and use of sleep medication.ResultsThe offspring and controls reported similar sleep patterns, with 33% sleeping ≥8 h and 17% napping in each group. At age 70, centenarians were more likely to have slept ≥8 h (55%) and to have napped (28%) compared with offspring and controls, p < 0.01. Among centenarians, no association was noted between sleep patterns and health outcomes. Sleeping for ≥8 h was associated with lower high-density lipoprotein cholesterol levels in the offspring and controls, and with insulin resistance in the offspring, but not with diabetes. Napping was associated with insulin resistance among the controls (p < 0.01), but not the offspring. Controls, but not offspring, who napped were 2.79 times more likely to have one or more of the following diseases: hypertension, myocardial infarction, stroke, or diabetes (OR 2.79, 95% CI 1.08–7.21, p = 0.04).ConclusionDespite being more likely to exhibit risky sleep patterns at age 70 compared with the offspring and controls, the centenarians were protected from age-related morbidities. The offspring of centenarians did exhibit metabolic disturbances in association with less healthy sleep patterns; however, unlike the controls, they were much less likely to manifest age-related diseases. This suggests that offspring may have inherited resilience genotypes from their centenarian parents that protect them against the harmful effects of sleep disturbances.

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The role of sleep duration in diabetes and glucose control

Cited by 23 publications

References 42 publications

Age-dependent changes in the association between sleep duration and impaired glucose metabolism

Age-dependent changes in the association between sleep duration and impaired glucose metabolism

Effect of exercise and dietary intervention on serum metabolomics in men with insomnia symptoms: a 6-month randomized-controlled trial

Association between Sleep Patterns and Health in Families with Exceptional Longevity

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