The role of short-chain fatty acids in kidney injury induced by gut-derived inflammatory response

Huang, Wei; Zhou, Luping; Guo, Hengli; Xu, Youhua; Xu, Yong

doi:10.1016/j.metabol.2016.11.006

Cited by 87 publications

(70 citation statements)

References 84 publications

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“…In fact, one of the important factors that participating in the health-preserving function of microbiota is their metabolites and the most important ones are short-chain fatty acids (SCFAs). SCFAs possess multiple beneficial functions (Huang et al 2017a) and some scholars even believe that these metabolites may be developed as potential target for drug design and therapy (Obrenovich et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…SCFAs can serve as the energy source for gut epithelial cells, couple with their receptors to function and promote the secretion of glucagon sample peptide 1 and 2 in intestinal L cells and so forth (Yadav et al 2013). There are mainly three forms of SCFAs namely acetate (60%), propionate (25%) and butyrate (15%) (Huang et al 2017a). Our previous study found that SCFAs could inhibit both high glucose and LPS-induced oxidative stress and inflammatory damage in glomerular mesangial cells (Huang et al 2017b), indicating their potential function in modulating diabetic-endotoxemia.…”

Section: Introductionmentioning

confidence: 99%

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Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice

Gao

Guo

et al. 2018

Journal of Endocrinology

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110

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Endotoxemia has been recognized to be closely accompanied with type 2 diabetes mellitus (T2DM) and is responsible for many diabetic complications. Recent study suggests the potential role of butyrate, a short-chain fatty acid (SCFA) from microbiota metabolite, on T2DM. Gut-leak is a key event in diabetic-endotoxemia. To investigate if butyrate could ameliorate diabetic-endotoxemia, both and experiments were carried out in the present study. The effect of butyrate supplementation on blood HbA1c and inflammatory cytokines were determined in db/db mice; gut barrier integrity and expression of tight junction proteins were investigated both and Oral butyrate administration significantly decreased blood HbA1c, inflammatory cytokines and LPS in db/db mice; inflammatory cell infiltration was reduced, and gut integrity and intercellular adhesion molecules were increased as detected by HE staining, immunohistochemistry and Western blot. By gut microbiota assay, ratio of Firmicutes:Bacteroidetes for gut microbiota was reduced by butyrate. In Caco-2 cells, butyrate significantly promoted cell proliferation, decreased inflammatory cytokines' secretion, enhanced cell anti-oxidative stress ability and preserved the epithelial monocellular integrity, which was damaged by LPS. The present findings demonstrated that butyrate supplementation could ameliorate diabetic-endotoxemia in db/db mice via restoring composition of gut microbiota and preserving gut epithelial barrier integrity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice

Gao

Guo

et al. 2018

Journal of Endocrinology

Self Cite

110

View full text Add to dashboard Cite

show abstract

“…In addition, SCFAs also "modulate different cell signal transduction processes via Gprotein-coupled receptors and act as epigenetic regulators by the inhibition of histone deacetylase and as potential mediators involved in the autophagy pathway." Though controversial, the SCFAs may be regarded as potential therapeutic targets and seem to represent the link between kidney damage and inflammatory response [70]. Gut inflammation is prevalent in CKD and is subsequently involved in systemic inflammation by disruption in the epithelial tight junction, leading to endotoxin and bacterial translocation; this state is associated with a defective Nrf2 pathway.…”

Section: Gut Microbiota As a Source Of Inflammation In Ckd: A Bidirecmentioning

confidence: 99%

Inflammation and Chronic Kidney Disease: Current Approaches and Recent Advances

Mihai¹,

Codrici²,

Popescu³

et al. 2018

Chronic Kidney Disease - From Pathophysiology to Clinical Improvements

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Despite being a "silent epidemic" disease, chronic kidney disease (CKD) is considered one of the major causes of mortality, together with its main complication, the cardiovascular disease, which contributes to the poor prognosis of these patients. Inflammation has been recognized as an essential part of CKD and is closely linked to cardiovascular complications. The identification of novel biomarkers using omics technologies is rapidly advancing and could improve the early detection in renal diseases. Omics approaches, including proteomics, could provide novel insights into disease mechanisms, identifying at the same time accurate inflammatory biomarker panels with an essential role in disease monitoring and follow-up. Recent advances highlight the gut microbiota as an important source of inflammation in kidney diseases. An increasing body of evidence reveals the cross talk between microbiota and host in CKD; in addition, gut dysbiosis may represent an underappreciated cause of inflammation and subsequently could lead to malnutrition, accelerated cardiovascular disease and CKD progression. This chapter discusses the relationship between inflammation and CKD and highlights the novel approaches regarding microbiota involvement in CKD pathology, as well as their potential to facilitate improving the quality of life.

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“…Bu nedenle bağırsakla böbrekler arasında bir bağlantı olduğu düşünülmektedir. Bağırsaklarda anaerobik bakteri fermentasyonunun ana metabolik ürünü olan kısa zincirli yağ asitlerinin intestinal fonksiyon ile ilişkili potansiyel medyatörler olup, kan dolaşımı ile inflamatuvar gen ekspresyonu, kemotaksis, diferansiyon, proliferasyon ve apoptozis aracılığıyla immün sistem ve mikrobiyota arasındaki bağlantıyı oluşturduğu düşünülmektedir (103,104). Kronik böbrek hastalığında disbiyosis giderek potansiyel bir tedavi hedefi olarak kabul ediliyor olmasına karşın bilimsel veriler henüz yeterli değildir (14).…”

Section: Probiyotikler Ve Prebiyotiklerunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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The role of short-chain fatty acids in kidney injury induced by gut-derived inflammatory response

Cited by 87 publications

References 84 publications

Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice

Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice

Inflammation and Chronic Kidney Disease: Current Approaches and Recent Advances

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

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