The Role of Sensation in Subjective and Objective Evaluation of Nasal Patency

Abstract

To assess if sensation of nasal mucosa affect the subjective sensation of nasal patency. This is a case control study with 50 patients, using 2% lignocaine as the active drug and normal saline as the placebo (2 groups of 25 patients each). Each subject had 2 ml of solution sprayed into the test nose. These subjects had no prior nasal symptoms, allergy or surgery. They were evaluated subjectively using Likert scale and objectively by acoustic rhinometry before and after lignocaine or normal saline. The patients in both normal saline and lignocaine groups demonstrated no significant change based upon Likert scale. The study also demonstrated the mean cross sectional area 1 (CSA1), mean cross sectional area 2 (CSA2), with mean Volume 1 and mean Volume 2, these results did not vary significantly in both groups with Acoustic Rhinometry. The analysis thus shows that the use of topical anesthetic spray on nasal mucosa produces no objective effect on nasal resistance or subjective sensation of altered nasal patency. Thus the study concludes that, tactile sensation of nasal mucosa does not play a role in the sensation of nasal obstruction.

The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue

“…The expansion of ADSCs in vitro will increase the rate of survival of transplanted cells, and improve the revADSCsularization of transplanted cells, decrease the rate of absorption, liquefaction, and fat cell infection for a successful single transplant shaping effect [ 8 – 10 ]. Patients given this treatment experience an improvement of symptoms associated with dryness of the nasal cavity and contradictory nasal resistance [ 11 ]. Although contradictory nasal resistance indicates that patients feel a subjective nasal obstruction, it is not consistent with nasal examinations that find substantially widened nasal cavity volumes [ 12 ].…”

Objective assessment of persistent rhinitis in Chinese and its relationship with serum indicators

“…Acoustic rhinometry detects acoustic signals reflected from the wall of the nasal cavity and calculates the minimum cross-sectional area (MCA) and nasal volume (NV) of the nose [7]. However, the results of rhinomanometry and acoustic rhinometry do not correlate well with subjective assessments, especially among healthy individuals [8][9][10]. The objective assessment of PR patients remains controversial, and few studies have objectively examined the difference between groups with and without a sensation of nasal congestion with PR.…”