The Role of Selenium Nutrition in the Development of Neonatal Rat Lung

Kim, H Y; Picciano, Mary Frances; Wallig, Matthew A.; Milner, John A.

doi:10.1203/00006450-199105010-00006

Cited by 25 publications

(14 citation statements)

References 28 publications

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“…The transient infant wheezing pattern is analogous to the transient early wheezing phenotype described in the study by MARTINEZ et al [32], which occurs with respiratory infections as a consequence of reduced airway calibre, and which disappears as the airways grow in size. In animals there is some evidence that maternal selenium deficiency during pregnancy leads to impaired lung development in the offspring [8]. Whilst maternal iron deficiency causes foetal growth retardation [14], effects on foetal lung growth do not appear to have been studied.…”

Section: Possible Causal Mechanismsmentioning

confidence: 99%

“…Whilst little is known about which specific nutrients might be involved, the antioxidant trace element selenium is of particular interest because it is thought to play an important role in lung development in animals [8]. Indirect evidence that prenatal exposure to antioxidants might influence the development of atopy comes from the observation that placental calcification, thought to be a marker of low antioxidant status in pregnancy [9], was associated with higher cord IgE [10].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

Shaheen

Newson

Henderson³

et al. 2004

Eur Respir J

150

111

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Section: Possible Causal Mechanismsmentioning

confidence: 99%

mentioning

confidence: 99%

Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

Shaheen

Newson

Henderson³

et al. 2004

Eur Respir J

150

111

View full text Add to dashboard Cite

“…There are three putative explanations for selenium's influence on the risk of wheezing during early childhood. Firstly, a number of animal studies have shown that maternal selenium deficiency is associated with impaired lung development . When the mother lacks selenium, oxidative stress is not adequately controlled and can therefore cause morphological and histological damage to the neonatal lung.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to selenium may protect against wheezing in children by the age of 3

Baïz

Chastang

Ibáñez

et al. 2016

Immunity Inflam & Disease

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IntroductionIt has been suggested that human in utero exposure to heavy metals such as selenium can reduce the prevalence of childhood asthma and allergic diseases. However, data on this topic are scarce. The objective of the present study was to assess the putative associations between maternal selenium level during pregnancy and the risk of asthma, wheezing, allergic rhinitis, and atopic dermatitis in children from the EDEN birth cohort by the age of 1 and 3 years.MethodsPlasma selenium concentrations were measured in maternal blood during mid‐pregnancy (24–28 weeks of gestation) in 861 mothers. Cohort children were followed up from birth to 3 years using health questionnaires filled out by the parents for asthma, wheezing, allergic rhinitis, and atopic dermatitis. Maternal plasma selenium was related to the childhood outcomes by the age of 1 and 3 years.ResultsOur results showed a significant negative association between a high maternal plasma selenium level during pregnancy and the risk of wheezing in the child by the age of 1 and 3 years. However, maternal plasma selenium during pregnancy was not associated with the prevalence of asthma, allergic rhinitis or atopic dermatitis.ConclusionsThe results of this study suggest that the level of fetal exposure to maternal selenium could have an influence on the risk of wheezing in infancy and potentially on the risk of developing asthma later in life.

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“…The inadequate selenium intakes in this vulnerable population are of concern. Studies in rats have previously shown that in utero selenium deficiency can impair neonatal lung development [42]. Maternal selenium status in French women was negatively associated with risk of wheezing in children aged 1–3 years; this could potentially lead to asthma later in life [43].…”

Section: Discussionmentioning

confidence: 99%

Selenium Intake in Iodine-Deficient Pregnant and Breastfeeding Women in New Zealand

et al. 2019

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Selenium plays a role in antioxidant status and, together with iodine, in thyroid function. Iodine deficiency exists in New Zealand during pregnancy and lactation, and selenium deficiency may further affect thyroid function. This study investigated selenium intakes of pregnant and lactating women, in Palmerston North, in the North Island of New Zealand. Dietary intake was estimated using three repeated 24-h dietary recalls. Dietary intake in pregnancy was also estimated from 24-h urinary excretion of selenium. Selenium concentrations were determined in urine and breastmilk using inductively-coupled plasma mass spectrometry. Median selenium intakes based on dietary data were 51 (39, 65) μg/day in pregnancy and 51 (36, 80) μg/day in lactation, with 61% and 68% below estimated average requirement (EAR). Median daily selenium intake in pregnancy based on urinary excretion was 49 (40, 60) µg/day, with 59% below EAR. Median selenium concentration in breastmilk was 11 (10, 13) µg/L and estimated median selenium intake for infants was 9 (8, 10) µg/day, with 91% below the Adequate Intake of 12 μg/day. These pregnant and breastfeeding women were at risk of dietary selenium inadequacy. Further research is required to assess selenium status in relation to thyroid function and health in this group.

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The Role of Selenium Nutrition in the Development of Neonatal Rat Lung

Cited by 25 publications

References 28 publications

Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

Prenatal exposure to selenium may protect against wheezing in children by the age of 3

Selenium Intake in Iodine-Deficient Pregnant and Breastfeeding Women in New Zealand

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