The role of <scp>DOG1</scp> immunohistochemistry in dermatopathology

Goto, Keisuke

doi:10.1111/cup.12787

Cited by 7 publications

(4 citation statements)

References 30 publications

(53 reference statements)

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“…Cutaneous mixed tumors have been thought to show multilineage differentiation along the lines of the folliculo-sebaceous-apocrine unit. 24 However, a previous report argued the possibility of eccrine differentiation in cutaneous mixed tumors, 29 which was supported by the results of our study. Cutaneous mixed tumors have also been reported…”

Section: Discussionsupporting

confidence: 91%

Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

Taniguchi,

Goto,

Yabushita

et al. 2023

J Cutan Pathol

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BackgroundTranscriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors.MethodsTRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues.ResultsThe normal epidermis was TRPS1−. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary‐like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2/3), nodular hidradenoma (4/5), spiradenoma (4/4), cutaneous mixed tumor (5/5), trichilemmal cyst (7/8), proliferating trichilemmal tumor (1/3), pilomatricoma (9/9), sebaceoma (2/5), extramammary Paget disease (13/13), sebaceous carcinoma (2/2), actinic keratosis (3/10), Bowen disease (7/12), and squamous cell carcinoma (1/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1−. All metastatic breast carcinoma cases (8/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1−.ConclusionsTRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.

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Section: Discussionsupporting

confidence: 91%

Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

Taniguchi,

Goto,

Yabushita

et al. 2023

J Cutan Pathol

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“…The main channels mediating Cl − secretion at the luminal membrane of sweat gland acinar cells are CaCCs [53, 66, 67]. Recent studies have shed light on the molecular nature of the CaCCs in murine and human sweat glands [53, 61, 66, 68, 69]. Bestrophin 2 (BEST2) is a CaCC that is necessary for sweat secretion as Best2 −/− mice showed a complete defect in spontaneous sweat production [61].…”

Section: Mechanism Of Salt and Fluid Secretion In Eccrine Sweat Glmentioning

confidence: 99%

Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry

Concepcion

Feske

2017

Cell Calcium

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Store-operated Ca2+ entry (SOCE) is a conserved mechanism of Ca2+ influx that regulates Ca2+ signaling in many cell types. SOCE is activated by depletion of endoplasmic reticulum (ER) Ca2+ stores in response to physiological agonist stimulation. After it was first postulated by J.W. Putney Jr. in 1986, SOCE has been described in a large number of non-excitable cell types including secretory cells of different exocrine glands. Here we discuss the mechanisms by which SOCE controls salt and fluid secretion in exocrine glands, with a special focus on eccrine sweat glands. In sweat glands, SOCE plays an important, non-redundant role in regulating the function of Ca2+-activated Cl− channels (CaCC), Cl− secretion and sweat production. In the absence of key regulators of SOCE such as the CRAC channel pore subunit ORAI1 and its activator STIM1, the Ca2+-activated chloride channel TMEM16A is inactive and fails to secrete Cl−, resulting in anhidrosis in mice and human patients.

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“…Fifty-nine out of 60 invasive carcinoma cases showed negativity and one case shows weak positive for p63 expression with a specificity of 1.66% which is higher than our study [ 5 ]. Goto has studied the role of DOG1 immunohistochemistry in dermatopathology which also showed that among 21 cases of fibroadenoma breast, nine cases were positive for DOG1 expression with specificity of 43% [ 13 ]. In a study conducted by Swalchick et al, nine out of 11 cases of fibroadenoma show DOG1 positivity with a specificity of 82% [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

DOG-1 as a Myoepithelial Marker in Discriminating Invasive Breast Carcinomas From Non-Invasive Breast Lesions

Perumandal¹,

Ponnaboina²,

Moula³

et al. 2023

Cureus

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Introduction The most common cancer in women is, by far, breast cancer. The incidence and mortality of breast cancer must be reduced by a multidisciplinary strategy that includes education campaigns, preventive measures, screening programmes for early diagnosis, and the availability of treatment facilities. The use of immunohistochemical (IHC) stains with relative specificity for myoepithelial markers has become a mainstay of standard diagnostic breast pathology because the presence and distribution of myoepithelial cells might differ greatly amongst the distinct breast proliferation. Although it has also been reported that DOG1 is expressed in other mesenchymal tumours, DOG1 has been demonstrated to be sensitive and specific for the detection of gastrointestinal stromal tumors (GISTs). Both myoepithelial cells (MECs) and luminal epithelial cells have occasionally displayed DOG1 immunoreactivity in the breast. Materials and methods This prospective cross-sectional study was done in the Department of Pathology at Osmania General Hospital, Hyderabad on 60 cases from June 2017 to June 2019. Female patients with different breast lesions including benign proliferating lesions, ductal carcinoma in-situ (DCIS), and invasive carcinoma breast cases were included in the study. Inflammatory lesions, mesenchymal, and metastatic tumors were excluded. IHC expression of DOG1 as a myoepithelial marker to discriminate invasive from non-invasive breast lesions was evaluated and correlated with clinicopathological features. Results The mean age of the study population was 33.67 ± 8.48 in the benign group and 54.43 ± 12.84 in the malignant group. Fifty percent (15) of the patients with benign lesions belonged to the age group 20-30 years, whereas 26.7% (8) of the patients with malignant lesions belonged to the age group 61-70 years. DOG-1 expression was strongly positive in fibroadenoma, ductal hyperplasia, fibrocystic disease, whereas strongly negative in malignant disease of the breast ( p < 0.0001). P63 expression was strongly positive in benign breast diseases and strongly negative in malignant diseases ( p < 0.0001). Conclusion DOG1 seems to be similar to p63 as a myoepithelial cell marker both in normal breast tissue and in benign lesions. DOG1 is strongly positive in benign breast diseases and strongly negative in malignant breast diseases. Hence, it can be considered as a useful myoepithelial marker in differentiating invasive breast carcinoma and non-invasive breast lesions.

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The role of DOG1 immunohistochemistry in dermatopathology

Abstract: DOG1 is a novel marker for identifying intercellular canaliculi and is a potential immunomarker of myoepithelial cells specific to mammary glands, anogenital mammary-like glands and tumors originating therein.

Cited by 7 publications

References 30 publications

Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry

DOG-1 as a Myoepithelial Marker in Discriminating Invasive Breast Carcinomas From Non-Invasive Breast Lesions

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