Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

Abstract

BackgroundTranscriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors.MethodsTRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues.ResultsThe normal epidermis was TRPS1−. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary‐like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2/3), nodular hidradenoma (4/5), spiradenoma (4/4), cutaneous mixed tumor (5/5), trichilemmal cyst (7/8), proliferating trichilemmal tumor (1/3), pilomatricoma (9/9), sebaceoma (2/5), extramammary Paget disease (13/13), sebaceous carcinoma (2/2), actinic keratosis (3/10), Bowen disease (7/12), and squamous cell carcinoma (1/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1−. All metastatic breast carcinoma cases (8/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1−.ConclusionsTRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.

TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall

“…However, recent studies challenge this notion, revealing that TRPS1 expression extends beyond breast neoplasms. Robust TRPS1 expression has been observed in various cutaneous epithelial neoplasms, including squamous cell carcinomas [ 2 , 3 ], mammary and extramammary Paget diseases [ 2 , 4 ], and adnexal neoplasms [ 3 , 5 , 6 , 7 ]. In dermatopathology, TRPS1 emerges as a valuable tool, particularly in distinguishing primary from secondary extramammary Paget disease, especially when arising in non-perianal cutaneous sites [ 4 ].…”

Pigmented Poroma of the Lower Eyelid: A Case Report and Literature Review

“…Recent research has revealed a genetic background to this disease, showing that about 85% of poroma cases are related with the following gene fusions: YAP1-MAML2, MAML2-YAP1, YAP1-NUTM1, and WWTR1-NUTM1, which are a consequence of intrachromosomal inversions and translocations [ 8 – 10 ]. NUT and transcriptional repressor GATA binding 1 (TRPS1) are potential molecular markers of poroma [ 11 , 12 ]. Ultraviolet radiation does not seem to be a key pathogenic factor in poroma development.…”